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Gene Review:

MEGF10 - multiple EGF-like-domains 10

Homo sapiens

Synonyms: KIAA1780, Multiple EGF-like domains protein 10, Multiple epidermal growth factor-like domains protein 10

Hamon, Y. et al., Nagase, T. et al.

Nagase, Nakayama, Nakajima, Kikuno, Ohara,

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High impact information on MEGF10

Indeed, the coexpression of either a functional or a mutant ABCA1 exerted a transdominant positive or negative modulation on the MEGF10-dependent engulfment [1].
We herein present the entire sequences of 100 cDNA clones of unidentified human genes, named KIAA1776 and KIAA1780-KIAA1878, from size-fractionated cDNA libraries derived from human fetal brain, adult whole brain, hippocampus and amygdala [2].

Biological context of MEGF10

We ascertained that, in a system of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7 [1].

References

Cooperation between Engulfment Receptors: The Case of ABCA1 and MEGF10. Hamon, Y., Trompier, D., Ma, Z., Venegas, V., Pophillat, M., Mignotte, V., Zhou, Z., Chimini, G. PLoS ONE (2006) [Pubmed]
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase, T., Nakayama, M., Nakajima, D., Kikuno, R., Ohara, O. DNA Res. (2001) [Pubmed]

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