The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

DOC2B  -  double C2-like domains, beta

Homo sapiens

Synonyms: DOC2BL, Doc2-beta, Double C2-like domain-containing protein beta
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on DOC2B

  • DOC2A was virtually brain specific, DOC2B ubiquitous [1].
  • We hypothesize that this novel Ca(2+)-induced activity of DOC2B functions synergistically with diacylglycerol-induced Munc13 binding to enhance exocytosis during episodes of high secretory activity [2].
  • Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane [2].
  • Purified DOC2B (expressed as a bacterial fusion protein) bound phospholipids in a Ca(2+)-dependent way, suggesting that the translocation is the result of a C2 domain activation mechanism [2].
  • Fluorescent-tagged DOC2A and DOC2B translocated to plasma membranes after [Ca(2+)](i) elevation [3].

References

  1. DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. Verhage, M., de Vries, K.J., Røshol, H., Burbach, J.P., Gispen, W.H., Südhof, T.C. Neuron (1997) [Pubmed]
  2. Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane. Groffen, A.J., Brian, E.C., Dudok, J.J., Kampmeijer, J., Toonen, R.F., Verhage, M. J. Biol. Chem. (2004) [Pubmed]
  3. DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties. Groffen, A.J., Friedrich, R., Brian, E.C., Ashery, U., Verhage, M. J. Neurochem. (2006) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities