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MeSH Review

Exocytosis

 
 
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Disease relevance of Exocytosis

 

Psychiatry related information on Exocytosis

 

High impact information on Exocytosis

  • In addition, ion channels may be involved in the regulation of the traffic of macromolecules by endocytosis, transcytosis, the biosynthetic-secretory pathway, and exocytosis, e.g., tissue factor pathway inhibitor, von Willebrand factor, and tissue plasminogen activator [7].
  • Plasma-membrane insertion of delta-opioid receptors (DORs) is induced by stimulus-triggered exocytosis of DOR-containing large dense-core vesicles (LDCVs), but how DORs become sorted into the regulated secretory pathway is unknown [8].
  • The SNARE complex, consisting of synaptobrevin, syntaxin, and SNAP-25, is essential for calcium-triggered exocytosis in neurosecretory cells [9].
  • Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor [10].
  • Introduction into hippocampal neurons of a dominant-negative endophilin construct, which constitutively binds to Ca2+ channels, significantly reduces endocytosis-mediated uptake of FM 4-64 dye without abolishing exocytosis [11].
 

Chemical compound and disease context of Exocytosis

 

Biological context of Exocytosis

 

Anatomical context of Exocytosis

 

Associations of Exocytosis with chemical compounds

  • These results provide support for the hypothesis that synaptotagmin, a Ca(2+)- and phospholipid-binding protein, is important for regulated exocytosis in neurons [27].
  • The mutants are defective in exocytosis, since they accumulate acetylcholine, and are resistant to cholinesterase inhibitors, but they nevertheless remain sensitive to cholinergic receptor agonists [28].
  • Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor [29].
  • Nitric oxide is a diffusible molecule with profound effects on regulated exocytosis in several biological systems-however, the molecular targets remain elusive [30].
  • In permeabilized cells, under conditions of fixed [Ca2+]c, added glutamate directly stimulates insulin exocytosis, independently of mitochondrial function [31].
 

Gene context of Exocytosis

  • Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis [32].
  • VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx [33].
  • It was half as potent as NAF/NAP-1 in inducing exocytosis but showed the same activity in the other responses [34].
  • We speculated that this IL-4-dependent, receptor-mediated response to the cys-LTs and UDP might induce cytokine generation by hMCs without concomitant exocytosis [35].
  • Vav1 was found to control activation of extracellular signal-regulated kinases and exocytosis of cytotoxic granules [36].
 

Analytical, diagnostic and therapeutic context of Exocytosis

References

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  21. Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophs. Tse, F.W., Tse, A., Hille, B., Horstmann, H., Almers, W. Neuron (1997) [Pubmed]
  22. Synaptic transmission persists in synaptotagmin mutants of Drosophila. DiAntonio, A., Parfitt, K.D., Schwarz, T.L. Cell (1993) [Pubmed]
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  30. S-nitrosylation of NSF controls membrane trafficking. Söllner, T.H., Sequeira, S. Cell (2003) [Pubmed]
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