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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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KIRREL3  -  kin of IRRE like 3 (Drosophila)

Homo sapiens

Synonyms: KIAA1867, KIRRE, Kin of IRRE-like protein 3, Kin of irregular chiasm-like protein 3, MRD4, ...
 
 
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High impact information on KIRREL3

  • The authors localized the expression of NEPH2 to the glomerular slit diaphragm by electron microscopy and show NEPH2 homodimerization and specific interactions with the extracellular domain of nephrin in vitro and in vivo [1].
  • NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases [1].
  • Here it colocalizes with the synaptic scaffolder calmodulin-associated serin/threonin kinase (CASK), and both Neph1 and Neph2 interact with the PDZ domain of CASK via their cytoplasmic tail [2].
 

Analytical, diagnostic and therapeutic context of KIRREL3

References

  1. NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. Gerke, P., Sellin, L., Kretz, O., Petraschka, D., Zentgraf, H., Benzing, T., Walz, G. J. Am. Soc. Nephrol. (2005) [Pubmed]
  2. Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. Gerke, P., Benzing, T., Höhne, M., Kispert, A., Frotscher, M., Walz, G., Kretz, O. J. Comp. Neurol. (2006) [Pubmed]
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