The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Kirrel3  -  kin of IRRE like 3 (Drosophila)

Mus musculus

Synonyms: 1500010O20Rik, 2900036G11Rik, Kiaa1867, Kin of IRRE-like protein 3, Kin of irregular chiasm-like protein 3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Kirrel3

  • Using the transgenic mouse in which the majority of OSNs express a particular OR, we identified such genes coding for the homophilic adhesive molecules Kirrel2/Kirrel3 and repulsive molecules ephrin-A5/EphA5 [1].
  • Our data suggest that mKirre is cleaved by metalloproteinases and that the extracellular domain of mKirre is responsible for supporting hematopoietic stem cells [2].
  • In the adult brain, mKirre mRNA was highly expressed in the olfactory bulb, the piriform cortex, the cochlear nucleus, and the cerebellum [3].
  • At embryonic day (E) 11.5, we could observe mKirre mRNA in the differentiating zones of various regions, such as the caudate-putamen, the geniculate body, the thalamus, the amygdala, and the brainstem [3].
  • SST-2, SST-3 and SST-4 were specific to L [4].

Anatomical context of Kirrel3

  • After birth, we could first observe high expression of mKirre mRNA in the glomerular and mitral layers of the olfactory bulb, the cortical plate of the neocortex, the cochlear nucleus, and the molecular and granule cell layers of the cerebellum [3].

Analytical, diagnostic and therapeutic context of Kirrel3

  • In the present study, to gain insights into the function of mKirre, we investigated the expression pattern of mKirre gene in the developing and adult mouse brain using in situ hybridization [3].


  1. A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting. Serizawa, S., Miyamichi, K., Takeuchi, H., Yamagishi, Y., Suzuki, M., Sakano, H. Cell (2006) [Pubmed]
  2. A stromal cell-derived membrane protein that supports hematopoietic stem cells. Ueno, H., Sakita-Ishikawa, M., Morikawa, Y., Nakano, T., Kitamura, T., Saito, M. Nat. Immunol. (2003) [Pubmed]
  3. Expression of mKirre, a mammalian homolog of Drosophila kirre, in the developing and adult mouse brain. Tamura, S., Morikawa, Y., Hisaoka, T., Ueno, H., Kitamura, T., Senba, E. Neuroscience (2005) [Pubmed]
  4. Inhibition of macrophage invasion by monoclonal antibodies specific to Leishmania (Viannia) braziliensis promastigotes and characterisation of their antigens. Silveira, T.G., Suzuki, E., Takahashi, H.K., Straus, A.H. Int. J. Parasitol. (2001) [Pubmed]
WikiGenes - Universities