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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPP1R16A  -  protein phosphatase 1, regulatory subunit 16A

Homo sapiens

Synonyms: MGC14333, MYPT3, Myosin phosphatase-targeting subunit 3, Protein phosphatase 1 regulatory subunit 16A
 
 
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High impact information on PPP1R16A

  • Deletion or mutations of this motif resulted in enhancement of the associated PP1c activity, suggesting that phosphorylation of MYPT3 may play an important role in regulating PP1c catalytic activity [1].
  • There is a direct interaction between the central conserved phosphorylated site motif with the N-terminal ankyrin repeat region; this interaction was significantly reduced with MYPT3 phosphorylation or acidic phosphorylation site mutations, with concomitant alterations in biochemical and morphological consequences [1].
  • MYPT3 aligns >99% with a region of mouse genomic DNA clone RP23-156P23 and localizes to chromosome 15, between markers at 44.1-46.5 cM, as demonstrated by radiation hybrid mapping [2].
  • MYPT3 is distinguished from related approximately 110-130 kDa MYPT subunits by its molecular mass of 58 kDa, and a unique C-terminal region that contains several potential signalling motifs and a CaaX prenylation site [2].

References

  1. Phosphorylation of Myosin Phosphatase Targeting Subunit 3 (MYPT3) and Regulation of Protein Phosphatase 1 by Protein Kinase A. Yong, J., Tan, I., Lim, L., Leung, T. J. Biol. Chem. (2006) [Pubmed]
  2. Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1. Skinner, J.A., Saltiel, A.R. Biochem. J. (2001) [Pubmed]
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