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Gene Review

HCM1  -  Hcm1p

Saccharomyces cerevisiae S288c

Synonyms: Forkhead transcription factor HCM1, High-copy suppressor of calmodulin protein 1, YCR065W, YCR65W, YCR902
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High impact information on HCM1

  • The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle [1].
  • As such, Hcm1 fills a significant gap in our understanding of the transcriptional circuitry that underlies the cell cycle [1].
  • This element is the binding site for the forkhead protein Hcm1, which is required for its cell cycle-specific activity [1].
  • Twentyfold overexpression of HCM1 permits strains carrying cmd1-1 to grow at temperatures up to and including 34 degrees C but does not suppress the lethality of either cmd1-1 at higher temperatures or the deletion of CMD1 [2].
  • HCM1 is not essential for growth, but deletion of HCM1 exacerbates the phenotype of a strain carrying cmd1-1 [2].

Biological context of HCM1

  • Deletion of HCM1 does not affect the basal level of SPC110 transcription, but reduces the induction that occurs late in G1 of the cell cycle [3].
  • HCM1 is located on chromosome III, which was recently sequenced [2].

Regulatory relationships of HCM1

  • Thus, overexpression of HCM1 enhances calmodulin function by an apparently indirect mechanism [2].

Other interactions of HCM1

  • Here we demonstrate that the effects of HCM1 are specific to the role of calmodulin at the spindle pole body [3].


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