High impact information on HCM1

• The Forkhead transcription factor Hcm1 regulates chromosome segregation genes and fills the S-phase gap in the transcriptional circuitry of the cell cycle [1].
• As such, Hcm1 fills a significant gap in our understanding of the transcriptional circuitry that underlies the cell cycle [1].
• This element is the binding site for the forkhead protein Hcm1, which is required for its cell cycle-specific activity [1].
• Twentyfold overexpression of HCM1 permits strains carrying cmd1-1 to grow at temperatures up to and including 34 degrees C but does not suppress the lethality of either cmd1-1 at higher temperatures or the deletion of CMD1 [2].
• HCM1 is not essential for growth, but deletion of HCM1 exacerbates the phenotype of a strain carrying cmd1-1 [2].

Biological context of HCM1

• Deletion of HCM1 does not affect the basal level of SPC110 transcription, but reduces the induction that occurs late in G1 of the cell cycle [3].
• HCM1 is located on chromosome III, which was recently sequenced [2].

Regulatory relationships of HCM1

• Thus, overexpression of HCM1 enhances calmodulin function by an apparently indirect mechanism [2].

Other interactions of HCM1

• Here we demonstrate that the effects of HCM1 are specific to the role of calmodulin at the spindle pole body [3].

References