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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

YPI1  -  Ypi1p

Saccharomyces cerevisiae S288c

Synonyms: Type 1 phosphatases regulator YPI1, YFR003C
 
 
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High impact information on YPI1

  • Because YPI1 is an essential gene, we have constructed conditional mutants that demonstrate that depletion of Ypi1 leads to alteration of nuclear localization of Glc7 and cell growth arrest in mid-mitosis with aberrant mitotic spindle [1].
  • Interestingly, the combination of equimolar amounts of Ypi1 and Sds22 leads to an almost full inhibition of Glc7 activity [1].
  • Ypi1 interacts physically in vitro with both Glc7 and Ppz1 phosphatase catalytic subunits, as shown by pull-down assays [2].

References

  1. YPI1 and SDS22 Proteins Regulate the Nuclear Localization and Function of Yeast Type 1 Phosphatase Glc7. Pedelini, L., Marquina, M., Ariño, J., Casamayor, A., Sanz, L., Bollen, M., Sanz, P., Garcia-Gimeno, M.A. J. Biol. Chem. (2007) [Pubmed]
  2. Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor. García-Gimeno, M.A., Muñoz, I., Ariño, J., Sanz, P. J. Biol. Chem. (2003) [Pubmed]
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