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Gene Review

ARP6  -  Arp6p

Saccharomyces cerevisiae S288c

Synonyms: Actin-like protein ARP6, L2393, L9449.13, YLR085C
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High impact information on ARP6

  • SUF3 encodes the nuclear ACTIN-RELATED PROTEIN6 (ARP6), the homolog of which in yeast is a component of an ATP-dependent chromatin-remodeling SWR1 complex [1].
  • entr1 mutant perturbed in correct perception of ambient temperature in Aarabidopsis was identified as an allele of arp6 (arp6-10). Evidence from genetics, molecular biology and chromatin biochemistry suggest that ARP6 contributes to temperature sensing through incorporating variant histone H2A.Z into chromatin. H2A.Z nucleosomes show a peculiar temperature dependent occupancy to provide correct temperature information to the cell to regulate transcription globally [2]


  1. SUPPRESSOR OF FRIGIDA3 encodes a nuclear ACTIN-RELATED PROTEIN6 required for floral repression in Arabidopsis. Choi, K., Kim, S., Kim, S.Y., Kim, M., Hyun, Y., Lee, H., Choe, S., Kim, S.G., Michaels, S., Lee, I. Plant Cell (2005) [Pubmed]
  2. H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis. Kumar, S.V., Wigge, P.A. Cell. (2010) [Pubmed]
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