High impact information on ATARP6

• However, suf3 showed only a partial reduction of FLC transcript level, although it largely suppressed the late-flowering phenotype [1].
• The suf3 mutation caused a decrease in the transcript level of FLC in both a FRI-containing line and autonomous pathway mutants [1].
• EARLY IN SHORT DAYS 1 (ESD1) encodes ACTIN-RELATED PROTEIN 6 (AtARP6), a putative component of chromatin remodelling complexes that positively regulates FLC accumulation in Arabidopsis [2].
• AtARP5, AtARP6, and AtARP8 each have distinct transcript expression patterns in seedlings, roots, leaves, flowers, and siliques [3].
• entr1 (enhanced temperature response 1) mutant perturbed in correct perception of ambient temperature in Aarabidopsis was identified as an allele of arp6 (arp6-10) [4]
• Evidence from genetics, molecular biologyand chromatin biochemistry suggest that ARP6 contributes to temperature sensingthrough incorporating variant histone H2A.Z into chromatin. H2A.Z nucleosomes show apeculiar temperature dependent occupancy to provide correct temperature information tothe cell to regulate transcription globally [4]

Biological context of ATARP6

• ESD1 encodes ARP6, a homolog of the actin-related protein family that shares moderate sequence homology with conventional actins [2].
• Using chromatin immunoprecipitation (ChIP) experiments, we have determined that ARP6 is required for both histone acetylation and methylation of the FLC chromatin in Arabidopsis [2].
• Chromatin immunoprecipitation analysis confirms that ARP6 is required for incorporation of H2A.Z into chromatin [4]

Other interactions of ATARP6

• AtARP4, AtARP5, and AtARP6 are orthologs of two classes of nuclear ARPs previously characterized in animals and fungi, BAF53s and ARP6s [3].

References