The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SWR1  -  Swr1p

Saccharomyces cerevisiae S288c

Synonyms: D9651.6, Helicase SWR1, Swi2/Snf2-related 1, YDR334W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on SWR1

  • Specific Htz1 deposition requires the SWR1 complex, which largely colocalizes with Htz1 [1].
  • Efficient deposition of H2A.Z is further promoted by a specific pattern of histone H3 and H4 tail acetylation and the bromodomain protein Bdf1, a component of the Swr1 remodeling complex that deposits H2A.Z [2].
  • Arp4 is also a subunit of the Ino80 and Swr1 chromatin remodeling complexes, which also interact with H2A P-Ser129 and are recruited to DSBs [3].
  • SUF3 encodes the nuclear ACTIN-RELATED PROTEIN6 (ARP6), the homolog of which in yeast is a component of an ATP-dependent chromatin-remodeling SWR1 complex [4].
  • Isw1 functions in parallel with the NuA4 and Swr1 complexes in stress-induced gene repression [5].
 

Biological context of SWR1

 

Other interactions of SWR1

  • This complex was designated SWR1-Com in reference to the Swr1p subunit, a Swi2/Snf2-paralog [9].

References

  1. Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. Zhang, H., Roberts, D.N., Cairns, B.R. Cell (2005) [Pubmed]
  2. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Raisner, R.M., Hartley, P.D., Meneghini, M.D., Bao, M.Z., Liu, C.L., Schreiber, S.L., Rando, O.J., Madhani, H.D. Cell (2005) [Pubmed]
  3. Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Downs, J.A., Allard, S., Jobin-Robitaille, O., Javaheri, A., Auger, A., Bouchard, N., Kron, S.J., Jackson, S.P., Côté, J. Mol. Cell (2004) [Pubmed]
  4. SUPPRESSOR OF FRIGIDA3 encodes a nuclear ACTIN-RELATED PROTEIN6 required for floral repression in Arabidopsis. Choi, K., Kim, S., Kim, S.Y., Kim, M., Hyun, Y., Lee, H., Choe, S., Kim, S.G., Michaels, S., Lee, I. Plant Cell (2005) [Pubmed]
  5. Isw1 functions in parallel with the NuA4 and Swr1 complexes in stress-induced gene repression. Lindstrom, K.C., Vary, J.C., Parthun, M.R., Delrow, J., Tsukiyama, T. Mol. Cell. Biol. (2006) [Pubmed]
  6. ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Mizuguchi, G., Shen, X., Landry, J., Wu, W.H., Sen, S., Wu, C. Science (2004) [Pubmed]
  7. Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling. Li, B., Pattenden, S.G., Lee, D., Gutiérrez, J., Chen, J., Seidel, C., Gerton, J., Workman, J.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Zhang, H., Richardson, D.O., Roberts, D.N., Utley, R., Erdjument-Bromage, H., Tempst, P., Côté, J., Cairns, B.R. Mol. Cell. Biol. (2004) [Pubmed]
  9. A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin. Kobor, M.S., Venkatasubrahmanyam, S., Meneghini, M.D., Gin, J.W., Jennings, J.L., Link, A.J., Madhani, H.D., Rine, J. PLoS Biol. (2004) [Pubmed]
 
WikiGenes - Universities