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Gene Review

ZRT2  -  low-affinity Zn(2+) transporter ZRT2

Saccharomyces cerevisiae S288c

Synonyms: L3120, L9606.9, Low-affinity zinc transport protein ZRT2, YLR130C, Zinc-regulated transporter 2
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High impact information on ZRT2

  • While ZRT1 is maximally induced during zinc limitation, ZRT2 is repressed in low zinc but remains induced upon zinc supplementation [1].
  • The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2 [1].

Anatomical context of ZRT2

  • A zrt1Delta zrt2Delta mutant (defective in the plasma membrane zinc transporters Zrt1p and Zrt2p) grown in the presence of zinc exhibited a phospholipid composition similar to that of wild type cells depleted for zinc [2].

Regulatory relationships of ZRT2

  • Under zinc limitation, ZRT1 and ZRT2 transcription is induced by the Zap1p transcriptional activator [3].

Other interactions of ZRT2

  • In yeast, zinc uptake is mediated by Zrt1p and Zrt2p, which belong to the ZIP family of metal transporters [3].
  • In this report, we describe the characterization of zinc-responsive elements (ZREs) in the promoters of the ZRT1, ZRT2, and ZAP1 genes [4].


  1. The Zap1 transcriptional activator also acts as a repressor by binding downstream of the TATA box in ZRT2. Bird, A.J., Blankman, E., Stillman, D.J., Eide, D.J., Winge, D.R. EMBO J. (2004) [Pubmed]
  2. Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc. Iwanyshyn, W.M., Han, G.S., Carman, G.M. J. Biol. Chem. (2004) [Pubmed]
  3. Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. MacDiarmid, C.W., Gaither, L.A., Eide, D. EMBO J. (2000) [Pubmed]
  4. Regulation of zinc homeostasis in yeast by binding of the ZAP1 transcriptional activator to zinc-responsive promoter elements. Zhao, H., Butler, E., Rodgers, J., Spizzo, T., Duesterhoeft, S., Eide, D. J. Biol. Chem. (1998) [Pubmed]
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