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Gene Review

NDST2  -  N-deacetylase/N-sulfotransferase (heparan...

Homo sapiens

Synonyms: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2, Glucosaminyl N-deacetylase/N-sulfotransferase 2, HSST2, N-HSST 2, N-heparan sulfate sulfotransferase 2, ...
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Disease relevance of NDST2

  • The N-terminal domain (A66-P604) of human NDST-2, designated as N-deacetylase (NDase), was cloned as a (His)(6)-fusion protein, and protein expression was carried out in Escherichia coli [1].

High impact information on NDST2

  • In NDST1(-/-) embryonic day 18.5 liver, in contrast, NDST2 was responsible for N-sulfation of the low sulfated HS [2].
  • Heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase isoform 2 (NDST-2), a key enzyme in the biosynthesis of heparin, contains two distinct activities [1].
  • In contrast, NDST 2 mRNA expression was reduced by 25 mM D-glucose in all groups (P<0.01) [3].

Other interactions of NDST2

  • The level of N-sulfation increased from 40% in control cells to 60% and 80%, respectively, in NDST-1 and NDST-2 transfected cells [4].


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