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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NDST2  -  N-deacetylase/N-sulfotransferase (heparan...

Homo sapiens

Synonyms: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2, Glucosaminyl N-deacetylase/N-sulfotransferase 2, HSST2, N-HSST 2, N-heparan sulfate sulfotransferase 2, ...
 
 
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Disease relevance of NDST2

  • The N-terminal domain (A66-P604) of human NDST-2, designated as N-deacetylase (NDase), was cloned as a (His)(6)-fusion protein, and protein expression was carried out in Escherichia coli [1].
 

High impact information on NDST2

  • In NDST1(-/-) embryonic day 18.5 liver, in contrast, NDST2 was responsible for N-sulfation of the low sulfated HS [2].
  • Heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase isoform 2 (NDST-2), a key enzyme in the biosynthesis of heparin, contains two distinct activities [1].
  • In contrast, NDST 2 mRNA expression was reduced by 25 mM D-glucose in all groups (P<0.01) [3].
 

Other interactions of NDST2

  • The level of N-sulfation increased from 40% in control cells to 60% and 80%, respectively, in NDST-1 and NDST-2 transfected cells [4].

References

  1. Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2. Duncan, M.B., Liu, M., Fox, C., Liu, J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. Enzymatically active N-deacetylase/n-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation. Ledin, J., Ringvall, M., Thuveson, M., Eriksson, I., Wil??n, M., Kusche-Gullberg, M., Forsberg, E., Kjell??n, L. J. Biol. Chem. (2006) [Pubmed]
  3. Influence of high glucose concentrations on the expression of glycosaminoglycans and N-deacetylase/N-sulphotransferase mRNA in cultured skin fibroblasts from diabetic patients with or without nephropathy. Yard, B., Feng, Y., Keller, H., Mall, C., van Der Woude, F. Nephrol. Dial. Transplant. (2002) [Pubmed]
  4. Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns. Pikas, D.S., Eriksson, I., Kjellén, L. Biochemistry (2000) [Pubmed]
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