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Gene Review

IFH1  -  Ifh1p

Saccharomyces cerevisiae S288c

Synonyms: L8083.9, Protein IFH1, RRP3, Ribosomal RNA-processing protein 3, YLR223C
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High impact information on IFH1

  • Phosphorylated CRF1 accumulates in the nucleus and competes with IFH1 for binding to FHL1 at RP gene promoters, and thereby inhibits transcription of RP genes [1].
  • 18S rRNA processing requires the RNA helicase-like protein Rrp3 [2].
  • Here we show that the transcription factors Fhl1 and Ifh1 associate almost exclusively with RP promoters; association depends on Rap1 and (to a lesser extent) a DNA element at many RP promoters [3].

Biological context of IFH1

  • IFH1 (located on chromosome IV) was isolated as a dosage-dependent suppressor partially correcting the growth defect of the fhl1 deletion [4].
  • In vitro transcription of a UAS(RAP1) enhancer-driven reporter gene requires both Rap1p and TFIID and is independent of the Fhl1p-Ifh1p coregulator [5].


  1. TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Martin, D.E., Soulard, A., Hall, M.N. Cell (2004) [Pubmed]
  2. 18S rRNA processing requires the RNA helicase-like protein Rrp3. O'Day, C.L., Chavanikamannil, F., Abelson, J. Nucleic Acids Res. (1996) [Pubmed]
  3. The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes. Wade, J.T., Hall, D.B., Struhl, K. Nature (2004) [Pubmed]
  4. The IFH1 gene product interacts with a fork head protein in Saccharomyces cerevisiae. Cherel, I., Thuriaux, P. Yeast (1995) [Pubmed]
  5. Yeast TFIID serves as a coactivator for Rap1p by direct protein-protein interaction. Garbett, K.A., Tripathi, M.K., Cencki, B., Layer, J.H., Weil, P.A. Mol. Cell. Biol. (2007) [Pubmed]
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