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Gene Review

CRF1  -  Crf1p

Saccharomyces cerevisiae S288c

Synonyms: Corepressor with FHL1 protein 1, Transcription factor CRF1, YD9934.08, YDR223W
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High impact information on CRF1

  • Phosphorylated CRF1 accumulates in the nucleus and competes with IFH1 for binding to FHL1 at RP gene promoters, and thereby inhibits transcription of RP genes [1].
  • Upon TOR inactivation, activated YAK1 phosphorylates and activates CRF1 [1].
  • A copper-responsive transcription factor, CRF1, mediates copper and cadmium resistance in Yarrowia lipolytica [2].
  • Our data suggest the existence of one or more different target genes for Crf1p, other than MTP or SOD1, and support its role as a novel copper-responsive transcription factor involved in metal detoxification [2].

Other interactions of CRF1

  • TOR, via PKA, negatively regulates YAK1 and maintains CRF1 in the cytoplasm [1].


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