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Gene Review:

CRF1 - Crf1p

Saccharomyces cerevisiae S288c

Synonyms: Corepressor with FHL1 protein 1, Transcription factor CRF1, YD9934.08, YDR223W

García, S. et al., Martin, D.E. et al.

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High impact information on CRF1

Phosphorylated CRF1 accumulates in the nucleus and competes with IFH1 for binding to FHL1 at RP gene promoters, and thereby inhibits transcription of RP genes [1].
Upon TOR inactivation, activated YAK1 phosphorylates and activates CRF1 [1].
A copper-responsive transcription factor, CRF1, mediates copper and cadmium resistance in Yarrowia lipolytica [2].
Our data suggest the existence of one or more different target genes for Crf1p, other than MTP or SOD1, and support its role as a novel copper-responsive transcription factor involved in metal detoxification [2].

Other interactions of CRF1

TOR, via PKA, negatively regulates YAK1 and maintains CRF1 in the cytoplasm [1].

References

TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Martin, D.E., Soulard, A., Hall, M.N. Cell (2004) [Pubmed]
A copper-responsive transcription factor, CRF1, mediates copper and cadmium resistance in Yarrowia lipolytica. García, S., Prado, M., Dégano, R., Domínguez, A. J. Biol. Chem. (2002) [Pubmed]

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