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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GEM1  -  ERMES complex Ca(2+)-binding regulatory...

Saccharomyces cerevisiae S288c

Synonyms: GTPase EF-hand protein of mitochondria 1, Mitochondrial Rho GTPase 1, YAL048C
 
 
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High impact information on GEM1

  • Cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria [1].
  • We show that Gem1p (yeast Miro; encoded by YAL048C) is a tail-anchored outer mitochondrial membrane protein [1].
  • Although overexpression of a mutant human Miro protein caused increased apoptotic activity in cultured cells (Fransson et al., 2003. J. Biol. Chem. 278:6495-6502), Gem1p is not required for pheromone-induced yeast cell death [1].
  • Genetic studies indicate both GTPase domains and EF-hand motifs, which are exposed to the cytoplasm, are required for Gem1p function [1].

References

  1. Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. Frederick, R.L., McCaffery, J.M., Cunningham, K.W., Okamoto, K., Shaw, J.M. J. Cell Biol. (2004) [Pubmed]
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