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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ERV46  -  Erv46p

Saccharomyces cerevisiae S288c

Synonyms: ER-derived vesicles protein ERV46, FUN9, YAL042W
 
 
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High impact information on ERV46

  • We determined signals in the Erv41p-Erv46p complex that are required for COPII-dependent export from the ER [1].
  • Three of the newly identified vesicle proteins (Erv29p, Erv41p, and Erv46p) represent uncharacterized integral membrane proteins that are conserved across species [2].
  • Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex [2].
  • Yeast endoplasmic reticulum (ER) vesicle protein Erv46p is a novel membrane protein involved in transport through the early secretory pathway [3].
  • Strains lacking a cycling Erv41p-Erv46p complex display a mild glycoprotein processing defect [4].
 

Biological context of ERV46

  • A cell-free assay that reproduces transport between the ER and Golgi indicates that deletion of the Erv41p-Erv46p complex influences the membrane fusion stage of transport [2].
 

Anatomical context of ERV46

References

  1. The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER. Otte, S., Barlowe, C. EMBO J. (2002) [Pubmed]
  2. Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. Otte, S., Belden, W.J., Heidtman, M., Liu, J., Jensen, O.N., Barlowe, C. J. Cell Biol. (2001) [Pubmed]
  3. Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae. Orci, L., Ravazzola, M., Mack, G.J., Barlowe, C., Otte, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Genetic and molecular interactions of the Erv41p-Erv46p complex involved in transport between the endoplasmic reticulum and Golgi complex. Welsh, L.M., Tong, A.H., Boone, C., Jensen, O.N., Otte, S. J. Cell. Sci. (2006) [Pubmed]
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