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Gene Review

ERV41  -  Erv41p

Saccharomyces cerevisiae S288c

Synonyms: ER-derived vesicles protein ERV41, YML067C
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High impact information on ERV41

  • We determined signals in the Erv41p-Erv46p complex that are required for COPII-dependent export from the ER [1].
  • Among the uncharacterized proteins, a 32-kDa protein termed ERGIC-32 is a novel cycling membrane protein with sequence homology to Erv41p and Erv46p, two proteins enriched in COPII vesicles of yeast [2].
  • Strains lacking a cycling Erv41p-Erv46p complex display a mild glycoprotein processing defect [3].
  • Recently, it was found to be a homolog of the yeast Erv41p, an endoplasmic reticulum (ER) resident protein involved in protein trafficking between ER and Golgi, and was renamed as ERGIC2 [4].

Biological context of ERV41

  • A cell-free assay that reproduces transport between the ER and Golgi indicates that deletion of the Erv41p-Erv46p complex influences the membrane fusion stage of transport [5].

Anatomical context of ERV41


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