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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ERV41  -  Erv41p

Saccharomyces cerevisiae S288c

Synonyms: ER-derived vesicles protein ERV41, YML067C
 
 
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High impact information on ERV41

  • We determined signals in the Erv41p-Erv46p complex that are required for COPII-dependent export from the ER [1].
  • Among the uncharacterized proteins, a 32-kDa protein termed ERGIC-32 is a novel cycling membrane protein with sequence homology to Erv41p and Erv46p, two proteins enriched in COPII vesicles of yeast [2].
  • Strains lacking a cycling Erv41p-Erv46p complex display a mild glycoprotein processing defect [3].
  • Recently, it was found to be a homolog of the yeast Erv41p, an endoplasmic reticulum (ER) resident protein involved in protein trafficking between ER and Golgi, and was renamed as ERGIC2 [4].
 

Biological context of ERV41

  • A cell-free assay that reproduces transport between the ER and Golgi indicates that deletion of the Erv41p-Erv46p complex influences the membrane fusion stage of transport [5].
 

Anatomical context of ERV41

References

  1. The Erv41p-Erv46p complex: multiple export signals are required in trans for COPII-dependent transport from the ER. Otte, S., Barlowe, C. EMBO J. (2002) [Pubmed]
  2. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. Breuza, L., Halbeisen, R., Jenö, P., Otte, S., Barlowe, C., Hong, W., Hauri, H.P. J. Biol. Chem. (2004) [Pubmed]
  3. Genetic and molecular interactions of the Erv41p-Erv46p complex involved in transport between the endoplasmic reticulum and Golgi complex. Welsh, L.M., Tong, A.H., Boone, C., Jensen, O.N., Otte, S. J. Cell. Sci. (2006) [Pubmed]
  4. PTX1(ERGIC2)-VP22 Fusion Protein Upregulates Interferon-beta in Prostate Cancer Cell Line PC-3. Kwok, S.C., Liu, X., Mangel, P., Daskal, I. DNA Cell Biol. (2006) [Pubmed]
  5. Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. Otte, S., Belden, W.J., Heidtman, M., Liu, J., Jensen, O.N., Barlowe, C. J. Cell Biol. (2001) [Pubmed]
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