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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TRM8  -  Trm8p

Saccharomyces cerevisiae S288c

Synonyms: D1075, Transfer RNA methyltransferase 8, YDL201W, tRNA (guanine(46)-N(7))-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase, ...
 
 
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Disease relevance of TRM8

 

High impact information on TRM8

  • We show here that m7G46 methyltransferase Trm8p/Trm82p acts as a hub of synthetic interactions with several tRNA modification enzymes, resulting in temperature-sensitive growth [2].
  • Multiple copies of tRNA(Val(AAC)) suppress the trm8-delta trm4-delta growth defect, directly implicating this tRNA in the phenotype [2].
  • We show that Saccharomyces cerevisiae strains lacking Trm8p/Trm82p tRNA m7G methyltransferase are temperature-sensitive in synthetic media containing glycerol [3].

References

  1. Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis. Purta, E., van Vliet, F., Tricot, C., De Bie, L.G., Feder, M., Skowronek, K., Droogmans, L., Bujnicki, J.M. Proteins (2005) [Pubmed]
  2. Rapid tRNA decay can result from lack of nonessential modifications. Alexandrov, A., Chernyakov, I., Gu, W., Hiley, S.L., Hughes, T.R., Grayhack, E.J., Phizicky, E.M. Mol. Cell (2006) [Pubmed]
  3. tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p. Alexandrov, A., Grayhack, E.J., Phizicky, E.M. RNA (2005) [Pubmed]
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