The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN41509     9-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: AC1MHZC4, AG-J-17401, CHEBI:19702, HMDB05862, CTK1A0934, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Guanosine, N-methyl-


High impact information on Guanosine, N-methyl-


Chemical compound and disease context of Guanosine, N-methyl-


Biological context of Guanosine, N-methyl-

  • Here we show that exposure of permeable trypanosome cells to S-adenosyl-L-homocysteine inhibits methylation of the nucleosides adjacent to 7-methylguanosine of newly synthesized SL RNA and prevents utilization of the SL RNA in trans splicing [12].
  • Eukaryotic translation initiation factor eIF-4E plays a central role in the recognition of the 7-methylguanosine-containing cap structure of mRNA and the formation of initiation complexes during protein synthesis. eIF-4E exists in both phosphorylated and nonphosphorylated forms, and the primary site of phosphorylation has been identified [13].
  • A preliminary study of the alkaline hydrolysis of the 7-methylguanosine residue that occurs at position 47 showed that at least two products are formed instead of only one as usually quoted in the literature [14].
  • The terminal 7-methylguanosine is recognized by cap-binding proteins that facilitate key events in gene expression including mRNA processing, transport, and translation [15].
  • In greater than 95% of the complexes observed for each type of ribosome, antibody contact was consistent with a single binding site, which places 7-methylguanosine near the junction of the upper one-third and lower two-thirds of the subunit and maximally distant from the platform [3].

Anatomical context of Guanosine, N-methyl-


Associations of Guanosine, N-methyl- with other chemical compounds


Gene context of Guanosine, N-methyl-


Analytical, diagnostic and therapeutic context of Guanosine, N-methyl-


  1. Translation in vitro of vesicular stomatitis virus mRNA lacking 5'-terminal 7-methylguanosine. Rose, J.K., Lodish, H.F. Nature (1976) [Pubmed]
  2. Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region. Trono, D., Pelletier, J., Sonenberg, N., Baltimore, D. Science (1988) [Pubmed]
  3. Ribosome structure. Localization of 7-methylguanosine in the small subunits of Escherichia coli and chloroplast ribosomes by immunoelectron microscopy. Trempe, M.R., Ohgi, K., Glitz, D.G. J. Biol. Chem. (1982) [Pubmed]
  4. Capping of tobacco mosaic virus RNA. Analysis of viral-coded guanylyltransferase-like activity. Dunigan, D.D., Zaitlin, M. J. Biol. Chem. (1990) [Pubmed]
  5. Specific inhibition of capped mRNA translation in vitro by m7G5'pppp5'G and m7G5'pppp5'm7G. Sasavage, N.L., Friderici, K., Rottman, F.M. Nucleic Acids Res. (1979) [Pubmed]
  6. Ribosome binding to reovirus mRNA in protein synthesis requires 5' terminal 7-methylguanosine. Both, G.W., Furuichi, Y., Muthukrishnan, S., Shatkin, A.J. Cell (1975) [Pubmed]
  7. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Seto, A.G., Zaug, A.J., Sobel, S.G., Wolin, S.L., Cech, T.R. Nature (1999) [Pubmed]
  8. Evidence for role of m7G5'-phosphate group in recognition of eukaryotic mRNA by initiation factor IF-M3. Shafritz, D.A., Weinstein, J.A., Safer, B., Merrick, W.C., Weber, L.A., Hickey, E.D., Baglioni, C. Nature (1976) [Pubmed]
  9. Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme. Hodel, A.E., Gershon, P.D., Quiocho, F.A. Mol. Cell (1998) [Pubmed]
  10. Tobacco mosaic virus RNA carries 5'-terminal triphosphorylated guanosine blocked by 5'-linked 7-methylguanosine. Keith, J., Fraenkel-Conrat, H. FEBS Lett. (1975) [Pubmed]
  11. Composition and Characterization of tRNA from Methanococcus vannielii. Best, A.N. J. Bacteriol. (1978) [Pubmed]
  12. Trans splicing in trypanosomes requires methylation of the 5' end of the spliced leader RNA. Ullu, E., Tschudi, C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  13. Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form. Minich, W.B., Balasta, M.L., Goss, D.J., Rhoads, R.E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. Isolation and characterization of valine transfer RNA from Saccharomyces cerevisiae. Aoyagi, S., Bhanot, O.S., Chambers, R.W. J. Biol. Chem. (1977) [Pubmed]
  15. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. Pillutla, R.C., Yue, Z., Maldonado, E., Shatkin, A.J. J. Biol. Chem. (1998) [Pubmed]
  16. Structural analysis of the messenger RNA cap-binding protein. Presence of phosphate, sulfhydryl, and disulfide groups. Rychlik, W., Gardner, P.R., Vanaman, T.C., Rhoads, R.E. J. Biol. Chem. (1986) [Pubmed]
  17. Inhibition of HeLa cell messenger RNA translation by 7-methylguanosine 5'-monophosphate. Weber, L.A., Feman, E.R., Hickey, E.D., Williams, M.C., Baglioni, C. J. Biol. Chem. (1976) [Pubmed]
  18. Yeast Eap1p, an eIF4E-associated protein, has a separate function involving genetic stability. Chial, H.J., Stemm-Wolf, A.J., McBratney, S., Winey, M. Curr. Biol. (2000) [Pubmed]
  19. A novel wobble rule found in starfish mitochondria. Presence of 7-methylguanosine at the anticodon wobble position expands decoding capability of tRNA. Matsuyama, S., Ueda, T., Crain, P.F., McCloskey, J.A., Watanabe, K. J. Biol. Chem. (1998) [Pubmed]
  20. Antigody-nucleic acid complexes. Inhibition of translation of silkmoth chorion messenger ribonucleic acid with antibodies specific for 7-methylguanosine. Munns, T.W., Morrow, C.S., Hunsley, J.R., Oberst, R.J., Liszewski, M.K. Biochemistry (1979) [Pubmed]
  21. 20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition. Bach, M., Winkelmann, G., Lührmann, R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  22. U2 small nuclear RNA 3' end formation is directed by a critical internal structure distinct from the processing site. Jacobson, M.R., Rhoadhouse, M., Pederson, T. Mol. Cell. Biol. (1993) [Pubmed]
  23. 7-Methylguanosine-dependent inhibition of globin mRNA translation by methylglyoxal. Kozarich, J.W., Deegan, J.L. J. Biol. Chem. (1979) [Pubmed]
  24. Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides. Bangs, J.D., Crain, P.F., Hashizume, T., McCloskey, J.A., Boothroyd, J.C. J. Biol. Chem. (1992) [Pubmed]
  25. A novel guanine-guanine base pairing: crystal structure of a complex between 7-methylguanosine and its iodide. Yamagata, Y., Fukumoto, S., Hamada, K., Fujiwara, T., Tomita, K. Nucleic Acids Res. (1983) [Pubmed]
  26. Functional characterization of five eIF4E isoforms in Caenorhabditis elegans. Keiper, B.D., Lamphear, B.J., Deshpande, A.M., Jankowska-Anyszka, M., Aamodt, E.J., Blumenthal, T., Rhoads, R.E. J. Biol. Chem. (2000) [Pubmed]
  27. Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII. Miura, T., Shiratori, Y., Shimma, N. J. Biomol. NMR (2003) [Pubmed]
  28. Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. Purushothaman, S.K., Bujnicki, J.M., Grosjean, H., Lapeyre, B. Mol. Cell. Biol. (2005) [Pubmed]
  29. The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. Wilson, K.F., Fortes, P., Singh, U.S., Ohno, M., Mattaj, I.W., Cerione, R.A. J. Biol. Chem. (1999) [Pubmed]
  30. Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2). Hausmann, S., Shuman, S. J. Biol. Chem. (2005) [Pubmed]
  31. Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells. Marino, M.W., Pfeffer, L.M., Guidon, P.T., Donner, D.B. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  32. Wheat germ cytoplasmic ribosomes. Localization of 7-methylguanosine and 6-methyladenosine by electron microscopy of immune complexes. Montesano, L., Glitz, D.G. J. Biol. Chem. (1988) [Pubmed]
  33. A competitive ELISA detecting 7-methylguanosine adduct induced by N-nitrosodimethylamine exposure. Niot-Mansart, V., Muhamedi, A., Arnould, J.P. Human & experimental toxicology. (2005) [Pubmed]
WikiGenes - Universities