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Gene Review

HNT1  -  Hnt1p

Saccharomyces cerevisiae S288c

Synonyms: Adenosine 5'-monophosphoramidase, HIT1, Hit family protein 1, YDL125C
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High impact information on HNT1

  • The target of Hnt1 regulation in this pathway was shown to be downstream of Cak1 and not to affect stability of Kin28 monomers [1].
  • Yeast strains constructed with specific loss of the Hnt1 active site fail to grow on galactose at elevated temperatures [1].
  • Functional complementation of all Hnt1 phenotypes was provided by rabbit Hint, which is only 22% identical to yeast Hnt1 but has very similar adenosine monophosphoramidase activity [1].


  1. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. Bieganowski, P., Garrison, P.N., Hodawadekar, S.C., Faye, G., Barnes, L.D., Brenner, C. J. Biol. Chem. (2002) [Pubmed]
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