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Gene Review

CAD1  -  Cad1p

Saccharomyces cerevisiae S288c

Synonyms: AP-1-like transcription activator YAP2, Cadmium resistance protein 1, D9461.12, Transcription factor CAD1, YAP2, ...
 
 
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Disease relevance of CAD1

 

High impact information on CAD1

  • Moreover, mutants in the proteasome are hypersensitive to cadmium, suggesting that cadmium resistance is mediated in part by degradation of abnormal proteins [2].
  • Our data explain the destabilizing properties of YAP2-type uORFs and also support a more general model for the mode of action of other known uORFs, such as those in the GCN4 mRNA [3].
  • Release of post-termination ribosomes from the YAP2 5'UTR causes accelerated decay which is largely independent of the termination modulator gene UPF1 [3].
  • The 5' untranslated region (5'UTR) of the Saccharomyces cerevisiae gene encoding the AP1-like transcription factor Yap2 contains two upstream open reading frames (uORF1 and uORF2) [3].
  • The YAP2-type of uORF functions as a cis-acting element that attenuates gene expression at the level of mRNA turnover via termination-dependent decay [3].
 

Biological context of CAD1

 

Anatomical context of CAD1

 

Associations of CAD1 with chemical compounds

 

Other interactions of CAD1

 

Analytical, diagnostic and therapeutic context of CAD1

  • We conclude that while Yap1p and Yap2p may have some overlapping functions they are clearly not redundant and, more generally, that DNA microarray analysis will be an important tool for distinguishing the functions of the large numbers of highly conserved genes found in all eukaryotic genomes [16].
  • Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p transcriptional networks [16].
  • By site-directed mutagenesis, it appeared that the mutation conferring cadmium resistance was a R970G-substitution in the C-terminal region of Pca1 protein [17].

References

  1. Characterization of an AP-1-like transcription factor that mediates an oxidative stress response in Kluyveromyces lactis. Billard, P., Dumond, H., Bolotin-Fukuhara, M. Mol. Gen. Genet. (1997) [Pubmed]
  2. Resistance to cadmium mediated by ubiquitin-dependent proteolysis. Jungmann, J., Reins, H.A., Schobert, C., Jentsch, S. Nature (1993) [Pubmed]
  3. Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability. Vilela, C., Ramirez, C.V., Linz, B., Rodrigues-Pousada, C., McCarthy, J.E. EMBO J. (1999) [Pubmed]
  4. Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae. Hirata, D., Yano, K., Miyakawa, T. Mol. Gen. Genet. (1994) [Pubmed]
  5. Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae. Lesuisse, E., Labbe, P. Microbiology (Reading, Engl.) (1995) [Pubmed]
  6. Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance. Bilsland, E., Molin, C., Swaminathan, S., Ramne, A., Sunnerhagen, P. Mol. Microbiol. (2004) [Pubmed]
  7. Cloning and characterization of CAD1/AAF1, a gene from Candida albicans that induces adherence to endothelial cells after expression in Saccharomyces cerevisiae. Fu, Y., Filler, S.G., Spellberg, B.J., Fonzi, W., Ibrahim, A.S., Kanbe, T., Ghannoum, M.A., Edwards, J.E. Infect. Immun. (1998) [Pubmed]
  8. Phytochelatin-cadmium-sulfide high-molecular-mass complexes of Euglena gracilis. Mendoza-C??zatl, D.G., Rodr??guez-Zavala, J.S., Rodr??guez-Enr??quez, S., Mendoza-Hernandez, G., Briones-Gallardo, R., Moreno-S??nchez, R. FEBS J. (2006) [Pubmed]
  9. Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Fernandes, L., Rodrigues-Pousada, C., Struhl, K. Mol. Cell. Biol. (1997) [Pubmed]
  10. Differential effect of cysteine-to-serine substitutions in metallothionein on cadmium resistance. Chernaik, M.L., Huang, P.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  11. The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1. Tommasini, R., Evers, R., Vogt, E., Mornet, C., Zaman, G.J., Schinkel, A.H., Borst, P., Martinoia, E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  12. Requirement of the N-terminal extension for vacuolar trafficking and transport activity of yeast Ycf1p, an ATP-binding cassette transporter. Mason, D.L., Michaelis, S. Mol. Biol. Cell (2002) [Pubmed]
  13. A novel family of cys-rich membrane proteins mediates cadmium resistance in Arabidopsis. Song, W.Y., Martinoia, E., Lee, J., Kim, D., Kim, D.Y., Vogt, E., Shim, D., Choi, K.S., Hwang, I., Lee, Y. Plant Physiol. (2004) [Pubmed]
  14. Molecular and genetic characterization of SLC1, a putative Saccharomyces cerevisiae homolog of the metazoan cytoplasmic dynein light chain 1. Dick, T., Surana, U., Chia, W. Mol. Gen. Genet. (1996) [Pubmed]
  15. Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. Lee, J., Godon, C., Lagniel, G., Spector, D., Garin, J., Labarre, J., Toledano, M.B. J. Biol. Chem. (1999) [Pubmed]
  16. Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p transcriptional networks. Cohen, B.A., Pilpel, Y., Mitra, R.D., Church, G.M. Mol. Biol. Cell (2002) [Pubmed]
  17. The cadmium-resistant gene, CAD2, which is a mutated putative copper-transporter gene (PCA1), controls the intracellular cadmium-level in the yeast S. cerevisiae. Shiraishi, E., Inouhe, M., Joho, M., Tohoyama, H. Curr. Genet. (2000) [Pubmed]
 
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