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Gene Review

PRP28  -  Prp28p

Saccharomyces cerevisiae S288c

Synonyms: Helicase CA8, Pre-mRNA-splicing ATP-dependent RNA helicase PRP28, YD8419.10C, YDR243C
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High impact information on PRP28

  • In addition, a suppressor of prp28-1 is a mutant allele of PRP8, which encodes a U5 protein, thus linking PRP28 with U5 [1].
  • Interestingly, double mutants containing conditional alleles of PRP28 and PRP24, which encodes a U6 snRNA-binding protein, are inviable [1].
  • These data are consistent with a scenario in which PRP28 acts to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing [1].
  • The growth and splicing defects are recessive and cosegregate, thus defining a single essential gene (PRP28) [1].
  • Here, we show that the function of an otherwise essential DEAD box protein, Prp28p, can be bypassed by mutations that alter either the protein U1-C or the U1 small nuclear RNA [2].

Biological context of PRP28

  • Using genetics, we identified the DExD/H box protein Prp28p as a potential mediator of the switch [3].

Anatomical context of PRP28

  • The allele snu114-60, which truncates the C terminus, was synthetically lethal with factors required for activation of the spliceosome, including the DExD/H-box ATPases BRR2 and PRP28 [4].

Analytical, diagnostic and therapeutic context of PRP28

  • The wild-type PRP28 gene was cloned, and sequence analysis reveals extensive homology to a family of proteins that are thought to function as ATP-dependent RNA helicases [1].


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