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Gene Review

RPN9  -  proteasome regulatory particle lid subunit...

Saccharomyces cerevisiae S288c

Synonyms: 26S proteasome regulatory subunit RPN9, D9461.14, NAS7, Proteasome non-ATPase subunit 7, YDR427W
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Disease relevance of RPN9

  • However, the NAS7, but not NAS6, disruptant cells caused high sensitivity to heat stress, being unable to proliferate at 37 degreesC [1].

High impact information on RPN9

  • We have isolated the RPN9 gene by two-hybrid screening with, as bait, RPN10 (formerly SUN1), which encodes a multiubiquitin chain receptor residing in the regulatory particle of the 26S proteasome [2].
  • Disruption of these yeast genes, NAS6 and NAS7, had no effect on cell viability, indicating that neither of the two subunits is essential for proliferation of yeast cells [1].
  • As anticipated from the fact that the rpn9 disruptant grew at 25 degrees C but arrested in G2/M phase at 37 degrees C, the CDK inhibitor Sic1p was found to be degraded at the G1/S boundary in the Deltarpn9 cells [3].


  1. cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Hori, T., Kato, S., Saeki, M., DeMartino, G.N., Slaughter, C.A., Takeuchi, J., Toh-e, A., Tanaka, K. Gene (1998) [Pubmed]
  2. Rpn9 is required for efficient assembly of the yeast 26S proteasome. Takeuchi, J., Fujimuro, M., Yokosawa, H., Tanaka, K., Toh-e, A. Mol. Cell. Biol. (1999) [Pubmed]
  3. Genetic dissection of the yeast 26S proteasome: cell cycle defects caused by the Deltarpn9 mutation. Takeuchi, J., Toh-e, A. Biochimie (2001) [Pubmed]
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