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Gene Review

HSP31  -  Hsp31p

Saccharomyces cerevisiae S288c

Synonyms: D9719.36, Heat shock protein 31, YDR533C
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Disease relevance of HSP31

  • The structure indicates that the closest relative to YDR533Cp is the Escherichia coli heat shock protein Hsp31 (YedU), which has both chaperone and protease activity [1].

High impact information on HSP31

  • HSP31 is induced under conditions of oxidative stress in a YAP1-dependent manner [2].
  • The deletion of the HSP31 gene displays no apparent phenotype under standard growth conditions, but a thorough functional analysis of S. cerevisiae revealed that its absence makes the cells sensitive to a subset of reactive oxygen species (ROS) generators [2].
  • Notably, the loss of HSP genes other than HSP31 enhanced the survival rate by about fivefold at 125 MPa, suggesting that the cellular defensive system against high pressure could be strengthened upon the loss of the HSP genes [3].
  • While the first four proteins have predicted active sites at dimer interfaces, YDR533Cp and Hsp31 both have predicted sites contained within each subunit [4].


  1. The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily. Wilson, M.A., St Amour, C.V., Collins, J.L., Ringe, D., Petsko, G.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Saccharomyces cerevisiae Hsp31p, a stress response protein conferring protection against reactive oxygen species. Skoneczna, A., Miciałkiewicz, A., Skoneczny, M. Free Radic. Biol. Med. (2007) [Pubmed]
  3. Systematic analysis of HSP gene expression and effects on cell growth and survival at high hydrostatic pressure in Saccharomyces cerevisiae. Miura, T., Minegishi, H., Usami, R., Abe, F. Extremophiles (2006) [Pubmed]
  4. Identification of functional subclasses in the DJ-1 superfamily proteins. Wei, Y., Ringe, D., Wilson, M.A., Ondrechen, M.J. PLoS Comput. Biol. (2007) [Pubmed]
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