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Gene Review

LSM8  -  Lsm8p

Saccharomyces cerevisiae S288c

Synonyms: J1464, U6 snRNA-associated Sm-like protein LSm8, YJR022W, YJR83.16
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High impact information on LSM8

  • This confirmed the association of the Lsm2p-Lsm8p complex with U6 snRNA [1].
  • These results provide evidence that Lhp1p is a molecular chaperone for polymerase III-transcribed RNAs and implicate Lsm8p as a key component in the very early steps of U6 snRNP assembly [2].
  • Here we report that mature heat shock and MET mRNAs that are trapped in the nucleus due to a block in mRNA export were strongly stabilized in strains lacking Lsm6p or the nucleus-specific Lsm8p protein but not by the absence of the cytoplasmic Lsm1p [3].
  • In the presence of extra U6 snRNA genes, LSM8 becomes dispensable for growth, suggesting that the only essential function of LSM8 is in U6 RNA biogenesis or function [4].

Other interactions of LSM8

  • A complex of seven Sm-like proteins, Lsm2-Lsm8, also binds the 3' end of U6 snRNA [4].
  • A mutation within the Sm motif of Lsm8p causes Saccharomyces cerevisiae cells to require the La protein Lhp1p to stabilize nascent U6 snRNA [4].


  1. A Sm-like protein complex that participates in mRNA degradation. Bouveret, E., Rigaut, G., Shevchenko, A., Wilm, M., Séraphin, B. EMBO J. (2000) [Pubmed]
  2. A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts. Pannone, B.K., Xue, D., Wolin, S.L. EMBO J. (1998) [Pubmed]
  3. Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex. Kufel, J., Bousquet-Antonelli, C., Beggs, J.D., Tollervey, D. Mol. Cell. Biol. (2004) [Pubmed]
  4. Multiple functional interactions between components of the Lsm2-Lsm8 complex, U6 snRNA, and the yeast La protein. Pannone, B.K., Kim, S.D., Noe, D.A., Wolin, S.L. Genetics (2001) [Pubmed]
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