The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

Gene Review: 

HTA2  -  histone H2A

Saccharomyces cerevisiae S288c

Synonyms: H2A2, Histone H2A.2, YBL003C, YBL0103
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on HTA2

  • Using these mutant (hta1- and hta2-) strains we find that neither H2A gene has a unique essential function during any phase of the yeast life cycle, although strains homozygous for hta1- grow more slowly [1].
  • In this case, HTA2-HTB2 amplifies via creation of a new, small, circular chromosome [2].
 

Biological context of HTA2

  • In this report, we demonstrate that either the HTA1 gene or the HTA2 gene, encoding the major H2As, can be completely replaced by disrupted genes in the polyploid, transcriptionally active macronucleus, indicating that neither of the two genes is essential [3].

References

  1. Histone H2A subtypes associate interchangeably in vivo with histone H2B subtypes. Kolodrubetz, D., Rykowski, M.C., Grunstein, M. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  2. Amplification of histone genes by circular chromosome formation in Saccharomyces cerevisiae. Libuda, D.E., Winston, F. Nature (2006) [Pubmed]
  3. Essential and nonessential histone H2A variants in Tetrahymena thermophila. Liu, X., Li, B., GorovskyMA, n.u.l.l. Mol. Cell. Biol. (1996) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities