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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PHO88  -  Pho88p

Saccharomyces cerevisiae S288c

Synonyms: Inorganic phosphate transport protein PHO88, Phosphate metabolism protein PHO88, YBR0835, YBR106W
 
 
 
 
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High impact information on PHO88

  • Both disruption and high dosage of PHO88 or PHO86 resulted in reduced Pi uptake [1].
  • A new gene, PHO88/ YBR106w, has now been identified as a multicopy suppressor of the rAPase- phenotype of the cells caused by the Pi inhibition of Pho81p [1].
  • The delta pho86 delta pho88 double disruption resulted in enhanced synthesis of rAPase under the high-Pi condition and conferred arsenate resistance on the cells than those in single disruptants of these genes [1].
 

Physical interactions of PHO88

  • These findings suggest that Pho88p is also involved in Pi transport and modulates Pho81p function together with Pho86p [1].

References

  1. A putative membrane protein, Pho88p, involved in inorganic phosphate transport in Saccharomyces cerevisiae. Yompakdee, C., Ogawa, N., Harashima, S., Oshima, Y. Mol. Gen. Genet. (1996) [Pubmed]
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