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Chemical Compound Review

orthoarsenate     dioxidoarsinic acid

Synonyms: AsO43-, AG-L-18862, CHEBI:48597, HAsO4(2-), CTK4D2999, ...
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Disease relevance of dioxidoarsinic acid


Psychiatry related information on dioxidoarsinic acid

  • Adsorption of arsenate by all soils was strongly kinetic, where the rate of As(V) retention was rapid initially and was followed by gradual or somewhat slow retention behavior with increasing reaction time [6].
  • This depression appears to be more pronounced, under strictly comparable conditions, when arsenate is used to stimulate ATP synthase activity than when the ornithine-citrulline conversion reaction is used for the same purpose [7].

High impact information on dioxidoarsinic acid

  • This is exemplified by the uptake of phosphate or its close analogue arsenate by bacterial cells by way of a high affinity active transport system dependent on a phosphate-binding protein; this system is unable to recognize other inorganic oxyanions and is, moreover, distinct from the one for sulphate transport [8].
  • In suspensions of tubules, arsenate increased oxygen consumption rates by 20.5 +/- 2.9% and decreased NADH fluorescence by 10.8 +/- 1.5% [9].
  • Arsenate induces stress proteins in cultured rat myoblasts [10].
  • Mutation of the Arabidopsis thaliana PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 (PHF1) impairs Pi transport, resulting in the constitutive expression of many Pi starvation-induced genes, increased arsenate resistance, and reduced Pi accumulation [11].
  • Arabidopsis thaliana plants transformed with the arsC gene expressed from a light-induced soybean rubisco promoter (SRS1p) strongly express ArsC protein in leaves, but not roots, and were consequently hypersensitive to arsenate [12].

Chemical compound and disease context of dioxidoarsinic acid


Biological context of dioxidoarsinic acid


Anatomical context of dioxidoarsinic acid


Associations of dioxidoarsinic acid with other chemical compounds

  • Endogenous plant arsenate reductase (ACR) activity converts arsenate to arsenite in roots, immobilizing arsenic below ground [17].
  • Vanadate and arsenate augmented the transfer reaction 200- and 2.5-fold, respectively, and lowered the pH optimum of the reaction [26].
  • A "triple cysteine redox relay" is proposed for the arsenate reduction mechanism [4].
  • The increase was measured in cells kept without glucose and with arsenate, where greater than 95% of intracellular radioactivity was recovered as free unesterified oleate [27].
  • The mechanism proposed here for the catalysis of arsenate reduction by pI258 ArsC involves a nucleophilic attack by Cys 10 on arsenate, the formation of a covalent intermediate and the transport of oxidative equivalents by a disulfide cascade [20].

Gene context of dioxidoarsinic acid


Analytical, diagnostic and therapeutic context of dioxidoarsinic acid

  • Laser Raman spectroscopy has been used to study a phosphate transfer reaction from ATP to Pi or arsenate in dimethyl sulfoxide [32].
  • Titration of the intrinsic tryptophan fluorescence of the weakly active AroA mutant, Asp313Ala (D313A), demonstrated a fluorescence decrease upon enolpyruvyl shikimate 3-phosphate (EPSP) binding, and a further decrease upon binding of phosphate or arsenate to AroA_D313A.EPSP, suggesting a further conformational change [33].
  • From other eyes retinas were isolated and maintained in organ culture, either untreated for 4 days maximum or for 21 hours during which the explants were treated the first 3 hours with selected doses of sodium arsenate or hydrogen peroxide [34].
  • The level of resistance of the bacterial populations to arsenate was determined by the DVCMR bioassay, and the results showed a linear correlation with the total arsenic concentrations in the monitoring well water samples; no correlation was observed by culture methods with the methods employed [35].
  • An arsenate reductase has been partially purified from human liver using ion exchange, molecular exclusion, hydroxyapatite chromatography, preparative isoelectric focusing, and electrophoresis [36].


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  17. Hyperaccumulation of arsenic in the shoots of Arabidopsis silenced for arsenate reductase (ACR2). Dhankher, O.P., Rosen, B.P., McKinney, E.C., Meagher, R.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  18. 31P nuclear magnetic resonance studies of glycogen phosphorylase from rabbit skeletal muscle: ionization states of pyridoxal 5'-phosphate. Feldmann, K., Hull, W.E. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
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  25. Phosphonocarboxylic acids as specific inhibitors of Na+-dependent transport of phosphate across renal brush border membrane. Szczepanska-Konkel, M., Yusufi, A.N., VanScoy, M., Webster, S.K., Dousa, T.P. J. Biol. Chem. (1986) [Pubmed]
  26. Evidence for a tyrosine residue at the active site of phosphoglucomutase and its interaction with vanadate. Layne, P.P., Najjar, V.A. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  27. Increase in membrane uptake of long-chain fatty acids early during preadipocyte differentiation. Abumrad, N.A., Forest, C.C., Regen, D.M., Sanders, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  28. Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Bun-Ya, M., Harashima, S., Oshima, Y. Mol. Cell. Biol. (1992) [Pubmed]
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  34. Oxidative stress induces heme oxygenase-1 immunoreactivity in Müller cells of mouse retina in organ culture. Ulyanova, T., Szél, A., Kutty, R.K., Wiggert, B., Caffé, A.R., Chader, G.J., van Veen, T. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
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