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Gene Review: 

AMN1  -  Amn1p

Saccharomyces cerevisiae S288c

Synonyms: Antagonist of mitotic exit network protein 1, CST13, Chromosome stability protein 13, ICS4, Increased copper-sensitivity protein 4, ...
 
 
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High impact information on AMN1

  • Positional cloning and functional assays showed that polymorphisms in GPA1 and AMN1 affect expression of genes involved in pheromone response and daughter cell separation, respectively [1].
  • We find that daughter cells activate an Antagonist of MEN pathway (AMEN) in part through induction of the Amn1 protein that binds directly to Tem1 and prevents its association with its target kinase Cdc15 [2].
  • Failure of Amn1 function results in defects of both the spindle assembly and nuclear orientation checkpoints and delays turning off Cdc14 in G1 [2].
  • Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling [2].

References

  1. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Yvert, G., Brem, R.B., Whittle, J., Akey, J.M., Foss, E., Smith, E.N., Mackelprang, R., Kruglyak, L. Nat. Genet. (2003) [Pubmed]
  2. Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Wang, Y., Shirogane, T., Liu, D., Harper, J.W., Elledge, S.J. Cell (2003) [Pubmed]
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