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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLX1  -  Slx1p

Saccharomyces cerevisiae S288c

Synonyms: Structure-specific endonuclease subunit SLX1, YBR1525, YBR228W
 
 
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High impact information on SLX1

  • The Slx1-Slx4 nuclease is active on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures [1].
  • Slx1 is required to generate approximately 50% of the spontaneous Rad22 DNA repair foci that occur in cycling cells [2].
  • The increased fork pausing at the replication fork barriers in the rDNA repeats in a strain that lacks Rqh1 DNA helicase is further increased by expression of a dominant negative form of Slx1 [2].
 

Biological context of SLX1

References

  1. Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Fricke, W.M., Brill, S.J. Genes Dev. (2003) [Pubmed]
  2. Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease. Coulon, S., Noguchi, E., Noguchi, C., Du, L.L., Nakamura, T.M., Russell, P. Mol. Biol. Cell (2006) [Pubmed]
  3. Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage. Flott, S., Rouse, J. Biochem. J. (2005) [Pubmed]
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