Gene Review:
SLX4 - Slx4p
Saccharomyces cerevisiae S288c
Synonyms:
L3140, Structure-specific endonuclease subunit SLX4, YLR135W
- Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3. Fricke, W.M., Brill, S.J. Genes Dev. (2003)
- Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Roberts, T.M., Kobor, M.S., Bastin-Shanower, S.A., Ii, M., Horte, S.A., Gin, J.W., Emili, A., Rine, J., Brill, S.J., Brown, G.W. Mol. Biol. Cell (2006)
- Multiple endonucleases function to repair covalent topoisomerase I complexes in Saccharomyces cerevisiae. Deng, C., Brown, J.A., You, D., Brown, J.M. Genetics (2005)
- Role of SGS1 and SLX4 in maintaining rDNA structure in Saccharomyces cerevisiae. Kaliraman, V., Brill, S.J. Curr. Genet. (2002)
- Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage. Flott, S., Rouse, J. Biochem. J. (2005)
- Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs. Zappulla, D.C., Maharaj, A.S., Connelly, J.J., Jockusch, R.A., Sternglanz, R. BMC Mol. Biol. (2006)