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Gene Review:

TSC10 - 3-dehydrosphinganine reductase

Saccharomyces cerevisiae S288c

Synonyms: 3-ketodihydrosphingosine reductase TSC10, KDS reductase, Temperature-sensitive CSG2 suppressor protein 10, YBR1734, YBR265W

Beeler, T. et al.

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Disease relevance of TSC10

His6-tagged Tsc10p was expressed in Escherichia coli and isolated by nickel-nitrilotriacetic acid column chromatography [1].

High impact information on TSC10

The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant [1].
The TSC10/YBR265w gene was found to encode 3-ketosphinganine reductase, the enzyme that catalyzes the second step in the synthesis of phytosphingosine, the long chain base found in yeast sphingolipids [1].
The tsc10 mutants accumulate 3-ketosphinganine and microsomal membranes isolated from tsc10 mutants have low 3-ketosphinganine reductase activity [1].

References

The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. Beeler, T., Bacikova, D., Gable, K., Hopkins, L., Johnson, C., Slife, H., Dunn, T. J. Biol. Chem. (1998) [Pubmed]

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AGOS_AEL164C	Ashbya gossypii ATCC 10895
KDSR	Gallus gallus
KLLA0F01749g	Kluyveromyces lactis NRRL Y-1140
MGG_00362	Magnaporthe oryzae 70-15
NCU00302	Neurospora crassa OR74A
SPCC1450.15	Schizosaccharomyces pombe 972h-

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