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Chemical Compound Review

AG-E-10692     2-amino-1-hydroxy-octadecan- 3-one

Synonyms: CHEBI:46966, CTK4D0716, AR-1D8116, AC1L19NY, AC1Q5H9R, ...
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High impact information on Ketodihydrosphingosine


Biological context of Ketodihydrosphingosine


Anatomical context of Ketodihydrosphingosine


Gene context of Ketodihydrosphingosine


  1. The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Nagiec, M.M., Baltisberger, J.A., Wells, G.B., Lester, R.L., Dickson, R.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. Gable, K., Slife, H., Bacikova, D., Monaghan, E., Dunn, T.M. J. Biol. Chem. (2000) [Pubmed]
  3. The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. Beeler, T., Bacikova, D., Gable, K., Hopkins, L., Johnson, C., Slife, H., Dunn, T. J. Biol. Chem. (1998) [Pubmed]
  4. Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity. Pinto, W.J., Wells, G.W., Lester, R.L. J. Bacteriol. (1992) [Pubmed]
  5. Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues. Merrill, A.H., Nixon, D.W., Williams, R.D. J. Lipid Res. (1985) [Pubmed]
  6. Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. Williams, R.D., Wang, E., Merrill, A.H. Arch. Biochem. Biophys. (1984) [Pubmed]
  7. D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis. Hanada, K., Hara, T., Nishijima, M. FEBS Lett. (2000) [Pubmed]
  8. Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. Tamura, K., Mitsuhashi, N., Hara-Nishimura, I., Imai, H. Plant Cell Physiol. (2001) [Pubmed]
  9. Sphingolipid biosynthesis in pathogenic fungi: Identification and characterization of the 3-ketosphinganine reductase activity of Candida albicans and Aspergillus fumigatus. Fornarotto, M., Xiao, L., Hou, Y., Koch, K.A., Chang, E., O'malley, R.M., Black, T.A., Cable, M.B., Walker, S.S. Biochim. Biophys. Acta (2006) [Pubmed]
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