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Gene Review: 

PPS1  -  Pps1p

Saccharomyces cerevisiae S288c

Synonyms: Dual specificity protein phosphatase PPS1, YBR2013, YBR276C
 
 
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Disease relevance of PPS1

  • The PPS1 protein was expressed in Escherichia coli, and the protein was shown to catalyze the hydrolysis of p-nitrophenyl phosphate, dephosphorylate phosphotyrosyl, and phosphothreonyl residues in synthetic diphosphorylated peptides and to inactivate the human ERK1 protein [1].
 

High impact information on PPS1

  • A screen for suppressors of this growth arrest identified the RAS2 gene as a multicopy suppressor of the PPS1p overexpression arrest [1].
  • The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle [1].
  • The deduced amino acid sequence of PPS1p shows similarity with protein-tyrosine phosphatases (PTPases) and is most closely related to a subfamily of PTPases that are capable of dephosphorylating phosphoseryl and phosphothreonyl residues as well as phosphotyrosyl residues [1].

References

  1. The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle. Ernsting, B.R., Dixon, J.E. J. Biol. Chem. (1997) [Pubmed]
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