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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GPI10  -  Gpi10p

Saccharomyces cerevisiae S288c

Synonyms: GPI mannosyltransferase 3, GPI mannosyltransferase III, GPI-MT-III, Glycosylphosphatidylinositol-anchor biosynthesis protein 10, YGL142C
 
 
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High impact information on GPI10

  • TbGPI10 also rescued the inviability of GPI10-disrupted S. cerevisiae, indicating that TbGPI10 is the orthologue of PIG-B/GPI10 that is involved in the transfer of the third mannose to GPI [1].
  • MCD4 is essential because Gpi10p, the mannosyltransferase adding the subsequent alpha1-2-linked mannose, requires substrates with an ethanolaminephosphate on the alpha1-4-linked mannose [2].
  • We have identified a protein encoded by the yeast open reading frame YGL142C that shares 33% identity with the human Pig-B protein [3].
  • YGL142C predicts a highly hydrophobic integral membrane protein which by sequence is related to ALG9, a yeast gene required for adding Man in alpha1,2 linkage to N-glycans [4].

References

  1. Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei. Nagamune, K., Nozaki, T., Maeda, Y., Ohishi, K., Fukuma, T., Hara, T., Schwarz, R.T., Sutterlin, C., Brun, R., Riezman, H., Kinoshita, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi. Zhu, Y., Vionnet, C., Conzelmann, A. J. Biol. Chem. (2006) [Pubmed]
  3. Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis. Sütterlin, C., Escribano, M.V., Gerold, P., Maeda, Y., Mazon, M.J., Kinoshita, T., Schwarz, R.T., Riezman, H. Biochem. J. (1998) [Pubmed]
  4. GPI anchor biosynthesis in yeast: phosphoethanolamine is attached to the alpha1,4-linked mannose of the complete precursor glycophospholipid. Canivenc-Gansel, E., Imhof, I., Reggiori, F., Burda, P., Conzelmann, A., Benachour, A. Glycobiology (1998) [Pubmed]
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