Gene Review:
MCD4 - Mcd4p
Saccharomyces cerevisiae S288c
Synonyms:
FSR2, GPI ethanolamine phosphate transferase 1, Morphogenesis checkpoint-dependent protein 4, SSU21, Supersecretion of u-PA protein 21, ...
- Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi. Zhu, Y., Vionnet, C., Conzelmann, A. J. Biol. Chem. (2006)
- Glycosylphosphatidylinositol (GPI) proteins of Saccharomyces cerevisiae contain ethanolamine phosphate groups on the alpha1,4-linked mannose of the GPI anchor. Imhof, I., Flury, I., Vionnet, C., Roubaty, C., Egger, D., Conzelmann, A. J. Biol. Chem. (2004)
- ATP uptake in the Golgi and extracellular release require Mcd4 protein and the vacuolar H+-ATPase. Zhong, X., Malhotra, R., Guidotti, G. J. Biol. Chem. (2003)
- YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast. Flury, I., Benachour, A., Conzelmann, A. J. Biol. Chem. (2000)
- Fluphenazine-resistant Saccharomyces cerevisiae mutants defective in the cell division cycle. Matsumoto, K., Uno, I., Ishikawa, T. J. Bacteriol. (1986)
- Genetic characterization of genes encoding enzymes catalyzing addition of phospho-ethanolamine to the glycosylphosphatidylinositol anchor in Saccharomyces cerevisiae. Toh-e, A., Oguchi, T. Genes Genet. Syst. (2002)
- Saccharomyces cerevisiae mutant displaying beta-glucans on cell surface. Sakai, Y., Azuma, M., Takada, Y., Umeyama, T., Kaneko, A., Fujita, T., Igarashi, K., Ooshima, H. J. Biosci. Bioeng. (2007)
- A genetic screen for ethanolamine auxotrophs in Saccharomyces cerevisiae identifies a novel mutation in Mcd4p, a protein implicated in glycosylphosphatidylinositol anchor synthesis. Storey, M.K., Wu, W.I., Voelker, D.R. Biochim. Biophys. Acta (2001)
- Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis. Yada, T., Sugiura, R., Kita, A., Itoh, Y., Lu, Y., Hong, Y., Kinoshita, T., Shuntoh, H., Kuno, T. J. Biol. Chem. (2001)