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Gene Review: 

ALG9  -  dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol...

Saccharomyces cerevisiae S288c

Synonyms: Alpha-1,2-mannosyltransferase ALG9, Asparagine-linked glycosylation protein 9, Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase, Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase, N1295, ...
 
 
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High impact information on ALG9

  • Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase [1].
  • The Saccharomyces cerevisiae alg (asparagine-linked glycosylation) mutants fail to synthesize oligosaccharide-lipid properly, and the alg9 mutant, accumulates Man(6)GlcNAc(2)-PP-Dol [2].
  • Here, we show that the dolichylphosphomannose-dependent ALG9 mannosyltransferase is the exception from this rule and is required for the addition of two different alpha-1,2-linked mannose residues to the LLO [3].
  • YGL142C predicts a highly hydrophobic integral membrane protein which by sequence is related to ALG9, a yeast gene required for adding Man in alpha1,2 linkage to N-glycans [4].

References

  1. Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase. Burda, P., te Heesen, S., Brachat, A., Wach, A., Düsterhöft, A., Aebi, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing. Cipollo, J.F., Trimble, R.B. J. Biol. Chem. (2000) [Pubmed]
  3. ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis. Frank, C.G., Aebi, M. Glycobiology (2005) [Pubmed]
  4. GPI anchor biosynthesis in yeast: phosphoethanolamine is attached to the alpha1,4-linked mannose of the complete precursor glycophospholipid. Canivenc-Gansel, E., Imhof, I., Reggiori, F., Burda, P., Conzelmann, A., Benachour, A. Glycobiology (1998) [Pubmed]
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