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Gene Review

PCL10  -  Pcl10p

Saccharomyces cerevisiae S288c

Synonyms: G2838, PHO85 cyclin-10, YGL134W
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Disease relevance of PCL10


High impact information on PCL10

  • We suggest a model for Pho85p function in the cell whereby cyclins like Pcl10p recruit Pho85p from a pool of monomers, both activating the kinase and targeting it to substrate [1].
  • Gsy2p phosphorylation required Pcl10p, occurred at physiologically relevant sites, and resulted in inactivation of Gsy2p [1].
  • Pcl10p is one of four Pcls with little sequence similarity to cyclins involved in cell cycle control [1].
  • In contrast, deletion of PCL8 and PCL10 in the coq3 mutant background partially restores glycogen accumulation [2].

Associations of PCL10 with chemical compounds


Other interactions of PCL10

  • In conjunction with Pcl8p and Pcl10p, Pho85p phosphorylates and regulates glycogen synthase [2].

Analytical, diagnostic and therapeutic context of PCL10

  • Gel filtration of yeast cell lysates demonstrated that most Pho85p was present as a monomer, although a portion coeluted in high-molecular-weight fractions with Pcl10p and Gsy2p [1].


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