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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

USE1  -  Use1p

Saccharomyces cerevisiae S288c

Synonyms: Protein transport protein USE1, SLT1, SNARE-like tail-anchored protein 1, Unconventional SNARE in the endoplasmic reticulum protein 1, YGL098W
 
 
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High impact information on USE1

  • The protein localized to the endoplasmic reticulum (ER) and was therefore named Use1p (unconventional SNARE in the ER) [1].
  • Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER [2].
  • Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-like tail-anchored protein 1 (Slt1) [2].
  • We also discovered that in vivo, Sly1p was associated with a SNARE complex formed on the ER, and that in vitro, the SM protein directly interacted with the ER-localized nonsyntaxin SNAREs Use1p/Slt1p and Sec20p [3].
  • After screening the whole collection, we identified two genes involved in ER to Golgi trafficking: RER2, a cis-prenyl transferase, and USE1, the function of which was unknown [4].
 

Other interactions of USE1

  • We demonstrated that repression of USE1 also leads to BiP secretion, and therefore likely affects retrograde, in addition to anterograde, ER to Golgi trafficking [4].

References

  1. Use1p is a yeast SNARE protein required for retrograde traffic to the ER. Dilcher, M., Veith, B., Chidambaram, S., Hartmann, E., Schmitt, H.D., Fischer von Mollard, G. EMBO J. (2003) [Pubmed]
  2. A SNARE required for retrograde transport to the endoplasmic reticulum. Burri, L., Varlamov, O., Doege, C.A., Hofmann, K., Beilharz, T., Rothman, J.E., Söllner, T.H., Lithgow, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Structure-based functional analysis reveals a role for the SM protein Sly1p in retrograde transport to the endoplasmic reticulum. Li, Y., Gallwitz, D., Peng, R. Mol. Biol. Cell (2005) [Pubmed]
  4. Yeast functional analysis: identification of two essential genes involved in ER to Golgi trafficking. Belgareh-Touzé, N., Corral-Debrinski, M., Launhardt, H., Galan, J.M., Munder, T., Le Panse, S., Haguenauer-Tsapis, R. Traffic (2003) [Pubmed]
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