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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GET1  -  Get1p

Saccharomyces cerevisiae S288c

Synonyms: Golgi to ER traffic protein 1, Guided entry of tail-anchored proteins 1, MDM39, Mitochondrial distribution and morphology protein 39, YGL020C
 
 
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High impact information on GET1

  • Here, we show that dsl1 mutants are defective for retrograde Golgi-to-ER traffic, even under conditions where no anterograde transport block is evident [1].
  • Golgi-specific glycosylation in the ER was reduced when Golgi-to-ER traffic was blocked, confirming that glycan extension in the ER was mainly due to recycling, rather than newly synthesized transferases [2].
  • In combination, our characterization of GET3 genetic and biochemical interactions with NPL4, GET1, and GET2 implicates Get3 in multiple membrane-dependent pathways [3].
  • Our findings imply a homeostatic role for Mdm39p, which may be related to the regulation of calcium ion fluxes in the ER, and is indispensable for mutants that lack Spf1p [4].

References

  1. Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit. Reilly, B.A., Kraynack, B.A., VanRheenen, S.M., Waters, M.G. Mol. Biol. Cell (2001) [Pubmed]
  2. Activity of recycling Golgi mannosyltransferases in the yeast endoplasmic reticulum. Karhinen, L., Makarow, M. J. Cell. Sci. (2004) [Pubmed]
  3. The Conserved ATPase Get3/Arr4 Modulates the Activity of Membrane-Associated Proteins in Saccharomyces cerevisiae. Auld, K.L., Hitchcock, A.L., Doherty, H.K., Frietze, S., Huang, L.S., Silver, P.A. Genetics (2006) [Pubmed]
  4. Cooperative function of the CHD5-like protein Mdm39p with a P-type ATPase Spf1p in the maintenance of ER homeostasis in Saccharomyces cerevisiae. Ando, A., Suzuki, C. Mol. Genet. Genomics (2005) [Pubmed]
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