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Gene Review

KAP122  -  Kap122p

Saccharomyces cerevisiae S288c

Synonyms: Importin beta-like protein KAP122, Karyopherin-122, PDR6, Pleiotropic drug resistance regulatory protein 6, YGL016W
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High impact information on KAP122

  • Recombinant GST-Kap122p formed a complex with recombinant His(6)-Toa1p/Toa2p [1].
  • Kap122p bound to nucleoporins, specifically, to the peptide repeat-containing fragments of Nup1p and Nup2p [1].
  • We discovered a nuclear import pathway mediated by the product of the previously identified Saccharomyces cerevisiae gene PDR6 (pleiotropic drug resistance) [1].
  • We have identified two proteins that have an important role in betabeta' nuclear localization: the importin beta homolog Kap122 and the WD40 repeat protein Wtm1 [2].
  • Subsequent tagging of Pdr6p with green fluorescent protein revealed association with the nuclear pore complexes in vivo [3].

Other interactions of KAP122

  • Together these data suggest that Kap122p is the major Kap for the import of Toa1p-Toa2p into the nucleus [1].


  1. The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. Titov, A.A., Blobel, G. J. Cell Biol. (1999) [Pubmed]
  2. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Zhang, Z., An, X., Yang, K., Perlstein, D.L., Hicks, L., Kelleher, N., Stubbe, J., Huang, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Purification of protein A-tagged yeast ran reveals association with a novel karyopherin beta family member, Pdr6p. Lau, D., Künzler, M., Braunwarth, A., Hellmuth, K., Podtelejnikov, A., Mann, M., Hurt, E. J. Biol. Chem. (2000) [Pubmed]
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