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Gene Review:

SPG1 - Spg1p

Saccharomyces cerevisiae S288c

Synonyms: G8578, Stationary phase gene 1 protein, YGR236C

Furge, K.A. et al., Aguilera, A.

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High impact information on SPG1

Byr4 inhibited the dissociation and hydrolysis of GTP bound to Spg1, but when Byr4 and Cdc16 were combined together they displayed Spg1GAP activity in vitro; Cdc16 alone had no detectable GAP activity [1].
The results suggest that the spg1 suppressor mutations allow S. cerevisiae pgil delta mutant strains to grow on glucose by using the Pentose-P cycle in combination with unusual strong respiration [2].

Analytical, diagnostic and therapeutic context of SPG1

Byr4 bound to Cdc16 and Spg1 in yeast two-hybrid assays and in coprecipitations in vitro and in yeast [1].

References

Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast. Furge, K.A., Wong, K., Armstrong, J., Balasubramanian, M., Albright, C.F. Curr. Biol. (1998) [Pubmed]
Mutations suppressing the effects of a deletion of the phosphoglucose isomerase gene PGI1 in Saccharomyces cerevisiae. Aguilera, A. Curr. Genet. (1987) [Pubmed]

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