The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CDC16  -  anaphase promoting complex subunit CDC16

Saccharomyces cerevisiae S288c

Synonyms: Anaphase-promoting complex subunit CDC16, Cell division control protein 16, YKL022C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on CDC16


Biological context of CDC16

  • The Cdc16, Cdc23, and Cdc27 proteins all contain several copies of the tetratricopeptide repeat and are subunits of a complex that is required for the onset of anaphase [4].
  • These observations distinguish CDC16 and CDC27 from other mutants that accumulate extra DNA after completing an aberrent mitosis, or skipping mitosis altogether, and entering a second, inappropriate G1 and S phase [1].
  • CDC16 and CDC27 may contribute to replication control by targeted proteolysis of an S phase initiator [1].
  • These results establish that CDC16 is required to prevent inappropriate firing of replication origins [2].
  • The MAK11 gene is close to CDC16 on chromosome XI [5].

Anatomical context of CDC16


Associations of CDC16 with chemical compounds


Other interactions of CDC16


Analytical, diagnostic and therapeutic context of CDC16


  1. The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Heichman, K.A., Roberts, J.M. Cell (1996) [Pubmed]
  2. CDC16 controls initiation at chromosome replication origins. Heichman, K.A., Roberts, J.M. Mol. Cell (1998) [Pubmed]
  3. Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. Rudner, A.D., Murray, A.W. J. Cell Biol. (2000) [Pubmed]
  4. TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast. Zachariae, W., Nasmyth, K. Mol. Biol. Cell (1996) [Pubmed]
  5. Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae. Icho, T., Lee, H.S., Sommer, S.S., Wickner, R.B. Basic Life Sci. (1986) [Pubmed]
  6. Uptake of endocytic markers into mitotic yeast cells. Nevalainen, L.T., Makarow, M. FEBS Lett. (1991) [Pubmed]
  7. Secretion of invertase in mitotic yeast cells. Makarow, M. EMBO J. (1988) [Pubmed]
  8. Isolation of yeast DNA replication mutants in permeabilized cells. Kuo, C., Nuang, H., Campbell, J.L. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  9. Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Richardson, P.M., Zon, L.I. Oncogene (1995) [Pubmed]
  10. Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability. Oshiro, G., Owens, J.C., Shellman, Y., Sclafani, R.A., Li, J.J. Mol. Cell. Biol. (1999) [Pubmed]
  11. Byr4, a dosage-dependent regulator of cytokinesis in S. pombe, interacts with a possible small GTPase pathway including Spg1 and Cdc16. Jwa, M., Song, K. Mol. Cells (1998) [Pubmed]
  12. Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast. Furge, K.A., Wong, K., Armstrong, J., Balasubramanian, M., Albright, C.F. Curr. Biol. (1998) [Pubmed]
WikiGenes - Universities