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Gene Review:

LIA1 - Lia1p

Saccharomyces cerevisiae S288c

Synonyms: DOHH, Deoxyhypusine dioxygenase, Deoxyhypusine hydroxylase, Deoxyhypusine monooxygenase, J1814, ...

Thompson, G.M. et al., Miyazaki, Y. et al., Park, J.H. et al.

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High impact information on LIA1

The Saccharomyces cerevisiae strain with deletion of YJR070C contained only deoxyhypusine but no hypusine, indicating that YJR070C was the single DOHH gene in this organism [1].
To identify eIF5A-binding proteins that could clarify its function, we screened a two-hybrid library and identified two eIF-5A partners in S. cerevisiae: Dys1 and the protein encoded by the gene YJR070C, named Lia1 (Ligand of eIF5A) [2].
The deduced 330 amino acid sequence of the product of mfbC gene (MFBC) was highly homologous to the 325 amino acid sequence of S. cerevisiae YJR070C/Lia1, the protein interacting with a putative translation initiation factor [3].

References

Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. Park, J.H., Aravind, L., Wolff, E.C., Kaevel, J., Kim, Y.S., Park, M.H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Mapping eIF5A binding sites for Dys1 and Lia1: in vivo evidence for regulation of eIF5A hypusination. Thompson, G.M., Cano, V.S., Valentini, S.R. FEBS Lett. (2003) [Pubmed]
Target genes of the developmental regulator PRIB of the mushroom Lentinula edodes. Miyazaki, Y., Sakuragi, Y., Yamazaki, T., Shishido, K. Biosci. Biotechnol. Biochem. (2004) [Pubmed]

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AgaP_AGAP002129	Anopheles gambiae str. PEST
AT3G58180	Arabidopsis thaliana
AGOS_AFR426C	Ashbya gossypii ATCC 10895
DOHH	Bos taurus
dohh-1	Caenorhabditis elegans
LOC485060	Canis lupus familiaris
dohh	Danio rerio
nero	Drosophila melanogaster
DOHH	Gallus gallus
DOHH	Homo sapiens
KLLA0B14080g	Kluyveromyces lactis NRRL Y-1140
DOHH	Macaca mulatta
MGG_01725	Magnaporthe oryzae 70-15
Dohh	Mus musculus
NCU05252	Neurospora crassa OR74A
Os12g0163300	Oryza sativa Japonica Group
Os12g0626100	Oryza sativa Japonica Group
DOHH	Pan troglodytes
Dohh	Rattus norvegicus
mmd1	Schizosaccharomyces pombe 972h-
LOC100145112	Xenopus (Silurana) tropicalis

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