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Gene Review

URA8  -  CTP synthase URA8

Saccharomyces cerevisiae S288c

Synonyms: CTP synthase 2, CTP synthetase 2, J1962, UTP--ammonia ligase 2, YJR103W
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Disease relevance of URA8


High impact information on URA8

  • The specific activities of the URA7-encoded and URA8-encoded enzymes with a Glu161 --> Lys (E161K) mutation were 2-fold greater when compared with the wild-type enzymes [2].
  • CTP potently inhibited (IC50 = 85 microM) URA8-encoded CTP synthetase activity and, in addition, caused the dependence of activity toward UTP to become cooperative [1].
  • URA8-encoded CTP synthetase was purified to apparent homogeneity by ammonium sulfate fractionation of the cytosolic fraction followed by chromatography with Q-Sepharose, Affi-Gel Blue, Mono Q, and Superose 6 [1].
  • Maximum URA8-encoded CTP synthetase activity was dependent on Mg2+ ions (Ka = 2.4 mM) and 2-mercaptoethanol at the pH optimum of 7 [1].

Biological context of URA8


  1. Differential biochemical regulation of the URA7- and URA8-encoded CTP synthetases from Saccharomyces cerevisiae. Nadkarni, A.K., McDonough, V.M., Yang, W.L., Stukey, J.E., Ozier-Kalogeropoulos, O., Carman, G.M. J. Biol. Chem. (1995) [Pubmed]
  2. Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae. Ostrander, D.B., O'Brien, D.J., Gorman, J.A., Carman, G.M. J. Biol. Chem. (1998) [Pubmed]
  3. Use of synthetic lethal mutants to clone and characterize a novel CTP synthetase gene in Saccharomyces cerevisiae. Ozier-Kalogeropoulos, O., Adeline, M.T., Yang, W.L., Carman, G.M., Lacroute, F. Mol. Gen. Genet. (1994) [Pubmed]
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