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Gene Review

Ctps  -  cytidine 5'-triphosphate synthase

Mus musculus

Synonyms: CTP synthase 1, CTP synthetase 1, Ctps1, UTP--ammonia ligase 1
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Disease relevance of Ctps


High impact information on Ctps


Chemical compound and disease context of Ctps


Biological context of Ctps

  • Biochemical phenotype of 5-fluorouracil-resistant murine T-lymphoblasts with genetically altered CTP synthetase activity [8].
  • This distinct inhibitory effect of the platinum compounds in the present experiments may be explained with the metabolic conversions of the compounds in the organism to their more active forms and/or with the inhibition of the protein biosynthesis under their influence because the lifetime of the CTP synthetase is short [6].

Associations of Ctps with chemical compounds


Other interactions of Ctps

  • The genetic loss of normal allosteric inhibition of the CTP synthetase activity in FURT-1A cells could account for the unusual phenotypic properties of these cells and conferred a high spontaneous mutator phenotype to cells possessing this mutation [8].


  1. Role of GTP in CTP synthetase from Ehrlich ascites tumor cells. Kizaki, H., Ohsaka, F., Sakurada, T. Biochem. Biophys. Res. Commun. (1982) [Pubmed]
  2. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. Lyons, S.D., Sant, M.E., Christopherson, R.I. J. Biol. Chem. (1990) [Pubmed]
  3. Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase. Kang, G.J., Cooney, D.A., Moyer, J.D., Kelley, J.A., Kim, H.Y., Marquez, V.E., Johns, D.G. J. Biol. Chem. (1989) [Pubmed]
  4. In situ regulation of mammalian CTP synthetase by allosteric inhibition. Aronow, B., Ullman, B. J. Biol. Chem. (1987) [Pubmed]
  5. Synthesis of N4-substituted CTP by mammalian CTP synthetase. Kizaki, H., Ohsaka, F., Sakurada, T. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  6. The effect of some platinum compounds on the activity of the CTP synthetase of Ehrlich ascites tumor cells: in vitro and in vivo studies. Ganeva, R.L., Spassovska, N.C., Genchev, D.D. J. Inorg. Biochem. (1991) [Pubmed]
  7. CTP synthetase from Ehrlich ascites tumor cells. Subunit stoichiometry and regulation of activity. Kizaki, H., Ohsaka, F., Sakurada, T. Biochim. Biophys. Acta (1985) [Pubmed]
  8. Biochemical phenotype of 5-fluorouracil-resistant murine T-lymphoblasts with genetically altered CTP synthetase activity. Aronow, B., Watts, T., Lassetter, J., Washtien, W., Ullman, B. J. Biol. Chem. (1984) [Pubmed]
  9. Regulation of pyrimidine biosynthesis in cultured L1210 cells by 3-deazauridine. Karle, J.M., Cysyk, R.L. Biochem. Pharmacol. (1984) [Pubmed]
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