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Chemical Compound Review

2-ME     2-sulfanylethanol

Synonyms: Thioglycol, Mercaptoetanol, Monothioglycol, Thiomonoglycol, M6250_ALDRICH, ...
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Disease relevance of Mercaptoethanol


Psychiatry related information on Mercaptoethanol


High impact information on Mercaptoethanol

  • This complex cannot be disrupted by boiling in SDS buffer containing 2-mercaptoethanol [10].
  • Enhancement of bovine pancreatic ribonuclease activity by mercaptoethanol [11].
  • Before and after reduction with 2-mercaptoethanol, a ratio of S/CSF antibody titers of less than or equal to 20 with either the passive hemagglutinating (PHA) or immune adherence hemagglutinating (IAHA) antibody tests occurred in every patient with HSVE [12].
  • Rat bone marrow was cultured for 4 wk in RPMI 1640 with 5% fetal calf serum and 2-mercaptoethanol to allow the formation of an adherent stromal cell layer containing NK precursor cells [13].
  • Various protease inhibitors had no or only a little effect, and mercaptoethanol and dithiothreitol strongly decreased the binding of 125I-PSTI [14].

Chemical compound and disease context of Mercaptoethanol


Biological context of Mercaptoethanol


Anatomical context of Mercaptoethanol

  • Nonspecific activation of murine lymphocytes. I. Proliferation and polyclonal activation induced by 2-mercaptoethanol and alpha-thioglycerol [24].
  • This 2-ME-treated FCS was able to substitute the function of adherent cells in the primary immune response against sheep red blood cells (SRBC) in vitro; Fractionation of 2-tme-treated FCS on a Sephadex G-100 column showed that 2-ME acted on a high molecular serum component which after activation, could substitute for macrophages [25].
  • Thymus-dependent (T) cells did not support significant 2-ME, alpha TG, or Concanavalin A responses in the absence of serum [24].
  • A substance which was mitogenic for murine B lymphocytes in the presence of 2-mercaptoethanol was isolated from agar [26].
  • The Fc gamma-binding protein was efficiently solubilized by a mixture of Na-EDTA and 2-mercaptoethanol, but not with one of these agents alone, indicating that both divalent cations and disulfide bridges are involved in the linkage of the Fc gamma-binding protein to the cell membrane [27].

Associations of Mercaptoethanol with other chemical compounds


Gene context of Mercaptoethanol


Analytical, diagnostic and therapeutic context of Mercaptoethanol


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