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Gene Review

CTPS1  -  CTP synthase 1

Homo sapiens

Synonyms: CTP synthetase 1, CTPS, IMD24, UTP--ammonia ligase 1
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Disease relevance of CTPS

  • The MOMP DNA vaccine but not the CTP synthetase DNA vaccine generated significant delayed-type hypersensitivity and serum antibodies to MoPn elementary bodies and reduced the peak growth of MoPn by >100-fold following lung challenge infection [1].
  • Thiourea dioxide was used in chemical modification studies to identify functionally important amino acids in Escherichia coli CTP synthetase [2].
  • Retinoic acid likely confers resistance of neuroblastoma cells to CPEC in part by slowing down proliferation, and in part by shifting the synthesis of CTP towards the salvage of cytidine, thereby bypassing CTP synthetase [3].
  • Therefore, the high activity of CTP synthetase in acute non-lymphocytic leukaemic cells can be inhibited by CPEC, which provides a key to a new approach for the treatment of ANLL [4].
  • (1) Acivicin competitively inhibited the activities of amidophosphoribosyl-transferase, CTP synthetase and carbamoyl-phosphate synthetase II from extracts of liver and hepatoma 3924A [5].

High impact information on CTPS


Chemical compound and disease context of CTPS


Biological context of CTPS


Anatomical context of CTPS


Associations of CTPS with chemical compounds


Other interactions of CTPS


Analytical, diagnostic and therapeutic context of CTPS

  • With the increasing complexity of radiotherapy computer treatment planning systems (CTPS), verification of the treatments is an important component of a quality assurance program [24].
  • Northern blot analyses of polyadenylated RNA from the resistant and sensitive cells indicated a 3-fold increase in transcripts of the CTP synthase gene in the resistant line [20].
  • Cyclopentenyl cytosine (CPEC) is a carbocyclic cytidine analog inhibitor of CTP synthetase and experimental drug for combination chemotherapy [25].
  • The coding region of G. intestinalis CTP synthetase was generated by PCR and subsequently cloned into the pQE30 vector for expression in E. coli [26].
  • The degree of CTP depletion of ALL cells after treatment with CPEC was positively correlated with the activity of CTP synthetase [27].


  1. DNA vaccination with the major outer-membrane protein gene induces acquired immunity to Chlamydia trachomatis (mouse pneumonitis) infection. Zhang, D., Yang, X., Berry, J., Shen, C., McClarty, G., Brunham, R.C. J. Infect. Dis. (1997) [Pubmed]
  2. Inactivation and covalent modification of CTP synthetase by thiourea dioxide. Robertson, J.G., Sparvero, L.J., Villafranca, J.J. Protein Sci. (1992) [Pubmed]
  3. Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells. Bierau, J., van Gennip, A.H., Leen, R., Caron, H.N., van Kuilenburg, A.B. FEBS Lett. (2002) [Pubmed]
  4. Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. Verschuur, A.C., Van Gennip, A.H., Leen, R., Muller, E.J., Elzinga, L., Voûte, P.A., Van Kuilenburg, A.B. Eur. J. Cancer (2000) [Pubmed]
  5. Multi-enzyme-targeted chemotherapy by acivicin and actinomycin. Weber, G., Prajda, N., Lui, M.S., Denton, J.E., Aoki, T., Sebolt, J., Zhen, Y.S., Burt, M.E., Faderan, M.A., Reardon, M.A. Adv. Enzyme Regul. (1982) [Pubmed]
  6. Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells. Whelan, J., Phear, G., Yamauchi, M., Meuth, M. Nat. Genet. (1993) [Pubmed]
  7. Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes. Yamauchi, M., Yamauchi, N., Meuth, M. EMBO J. (1990) [Pubmed]
  8. Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma. Bierau, J., van Gennip, A.H., Leen, R., Meinsma, R., Caron, H.N., van Kuilenburg, A.B. Cancer Chemother. Pharmacol. (2006) [Pubmed]
  9. Purification and properties of CTP synthetase from Ehrlich ascites tumor cells. Kizaki, H., Sakurada, T., Weber, G. Biochim. Biophys. Acta (1981) [Pubmed]
  10. Chromosome mapping of the human cytidine-5'-triphosphate synthetase (CTPS) gene to band 1p34.1-p34.3 by fluorescence in situ hybridization. Takahashi, E., Yamauchi, M., Tsuji, H., Hitomi, A., Meuth, M., Hori, T. Hum. Genet. (1991) [Pubmed]
  11. Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS). Yamauchi, M., Yamauchi, N., Phear, G., Spurr, N.K., Martinsson, T., Weith, A., Meuth, M. Genomics (1991) [Pubmed]
  12. Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. Han, G.S., Sreenivas, A., Choi, M.G., Chang, Y.F., Martin, S.S., Baldwin, E.P., Carman, G.M. J. Biol. Chem. (2005) [Pubmed]
  13. Cytidine triphosphate (CTP) synthetase activity during cell cycle progression in normal and malignant T-lymphocytic cells. van den Berg, A.A., van Lenthe, H., Kipp, J.B., de Korte, D., van Kuilenburg, A.B., van Gennip, A.H. Eur. J. Cancer (1995) [Pubmed]
  14. Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells. Verschuur, A.C., Van Gennip, A.H., Muller, E.J., Voûte, P.A., Vreken, P., Van Kuilenburg, A.B. Biol. Chem. (1999) [Pubmed]
  15. Purification of cytidine-triphosphate synthetase from rat liver, and demonstration of monomer, dimer and tetramer. Thomas, P.E., Lamb, B.J., Chu, E.H. Biochim. Biophys. Acta (1988) [Pubmed]
  16. The roles of uridine-cytidine kinase and CTP synthetase in the synthesis of CTP in malignant human T-lymphocytic cells. van den Berg, A.A., van Lenthe, H., Busch, S., de Korte, D., van Kuilenburg, A.B., van Gennip, A.H. Leukemia (1994) [Pubmed]
  17. Synthesis of Methylene- and Difluoromethylenephosphonate Analogues of Uridine-4-phosphate and 3-Deazauridine-4-phosphate. Taylor, S.D., Mirzaei, F., Sharifi, A., Bearne, S.L. J. Org. Chem. (2006) [Pubmed]
  18. Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness. Hofer, A., Steverding, D., Chabes, A., Brun, R., Thelander, L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  19. Effects of pyrimidine antagonists on sialic acid regeneration in HL-60 cells. Hindenburg, A.A., Taub, R.N., Grant, S., Chang, G., Baker, M.A. Cancer Res. (1985) [Pubmed]
  20. Resistance to cyclopentenylcytosine in murine leukemia L1210 cells. Zhang, H., Cooney, D.A., Zhang, M.H., Ahluwalia, G., Ford, H., Johns, D.G. Cancer Res. (1993) [Pubmed]
  21. Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum. Reyes, P., Rathod, P.K., Sanchez, D.J., Mrema, J.E., Rieckmann, K.H., Heidrich, H.G. Mol. Biochem. Parasitol. (1982) [Pubmed]
  22. Biochemical assessment of the effects of acivicin and dipyridamole given as a continuous 72-hour intravenous infusion. Fischer, P.H., Willson, J.K., Risueno, C., Tutsch, K., Bruggink, J., Ranhosky, A., Trump, D.L. Cancer Res. (1988) [Pubmed]
  23. The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate. van Berg, A.A., Mooyer, P.A., van Lenthe, H., Stet, E.H., De Abreu, R.A., van Kuilenburg, A.B., van Gennip, A.H. Biochem. Pharmacol. (1995) [Pubmed]
  24. An independent check method of radiotherapy computer plan derived monitor units. Hill, R.F., Perez, M.D., Beckham, W.A. Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine. (1998) [Pubmed]
  25. CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase. Huang, M., Wang, Y., Collins, M., Graves, L.M. Leukemia (2004) [Pubmed]
  26. Isolation, characterization and expression of the gene encoding cytidine triphosphate synthetase from Giardia intestinalis. Lim, R.L., O'Sullivan, W.J., Stewart, T.S. Mol. Biochem. Parasitol. (1996) [Pubmed]
  27. In vitro inhibition of cytidine triphosphate synthetase activity by cyclopentenyl cytosine in paediatric acute lymphocytic leukaemia. Verschuur, A.C., Van Gennip, A.H., Leen, R., Meinsma, R., Voute, P.A., van Kuilenburg, A.B. Br. J. Haematol. (2000) [Pubmed]
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