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Gene Review:

BCAS1 - breast carcinoma amplified sequence 1

Homo sapiens

Synonyms: AIBC1, Amplified and overexpressed in breast cancer, Breast carcinoma-amplified sequence 1, NABC1, Novel amplified in breast cancer 1

Zhao, C. et al., Collins, C. et al., Correa, R.G. et al., Burmester, J.K. et al.

Burmester, Suarez, Lin, Jin, Miller, Zhang, Salzman, Reding, Catalona,

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Disease relevance of BCAS1

NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors [1].
NABC1 is predicted to encode a 585-aa protein of unknown function and is overexpressed in most but not all breast cancer cell lines in which it was amplified [2].

High impact information on BCAS1

ZNF217 and NABC1 emerged as strong candidate oncogenes and were characterized in detail [2].
Also in this report, we confirm that NABC1 is overexpressed in breast tumors and show that both NABC1 and NABC1_5B are downregulated in colorectal tumors [1].
SNPs in three of these genes (BCAS1, EMP3 and MLH1) remained significant in an age-matched subsample [3].
RESULTS: Elevated expression of NABC1 was significantly associated with positive estrogen (P < 0.001) and progesterone (P = 0.027) receptors in breast tumors, and high expression of PTK6 was significantly correlated with positive estrogen receptor status (P = 0.022) and postmenopausal status (P = 0.008) [4].

Other interactions of BCAS1

Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma [2].

References

NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors. Correa, R.G., de Carvalho, A.F., Pinheiro, N.A., Simpson, A.J., de Souza, S.J. Genomics (2000) [Pubmed]
Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Collins, C., Rommens, J.M., Kowbel, D., Godfrey, T., Tanner, M., Hwang, S.I., Polikoff, D., Nonet, G., Cochran, J., Myambo, K., Jay, K.E., Froula, J., Cloutier, T., Kuo, W.L., Yaswen, P., Dairkee, S., Giovanola, J., Hutchinson, G.B., Isola, J., Kallioniemi, O.P., Palazzolo, M., Martin, C., Ericsson, C., Pinkel, D., Albertson, D., Li, W.B., Gray, J.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Analysis of candidate genes for prostate cancer. Burmester, J.K., Suarez, B.K., Lin, J.H., Jin, C.H., Miller, R.D., Zhang, K.Q., Salzman, S.A., Reding, D.J., Catalona, W.J. Hum. Hered. (2004) [Pubmed]
Elevated expression levels of NCOA3, TOP1, and TFAP2C in breast tumors as predictors of poor prognosis. Zhao, C., Yasui, K., Lee, C.J., Kurioka, H., Hosokawa, Y., Oka, T., Inazawa, J. Cancer (2003) [Pubmed]

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